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dc.contributor.authorBeck, Emily Claire
dc.contributor.authorLohman, Brooke L.
dc.contributor.authorTabakh, Daniel B.
dc.contributor.authorKieweg, Sarah L.
dc.contributor.authorGehrke, Stevin H.
dc.contributor.authorBerkland, Cory J.
dc.contributor.authorDetamore, Michael S.
dc.date.accessioned2017-05-10T16:29:57Z
dc.date.available2017-05-10T16:29:57Z
dc.date.issued2015-10
dc.identifier.citationBeck, E. C., Lohman, B. L., Tabakh, D. B., Kieweg, S. L., Gehrke, S. H., Berkland, C. J., & Detamore, M. S. (2015). Enabling Surgical Placement of Hydrogels through Achieving Paste-Like Rheological Behavior in Hydrogel Precursor Solutions. Annals of Biomedical Engineering, 43(10), 2569–2576. http://doi.org/10.1007/s10439-015-1277-8en_US
dc.identifier.urihttp://hdl.handle.net/1808/24063
dc.description.abstractHydrogels are a promising class of materials for tissue regeneration, but they lack the ability to be molded into a defect site by a surgeon because hydrogel precursors are liquid solutions that are prone to leaking during placement. Therefore, although the main focus of hydrogel technology and developments are on hydrogels in their crosslinked form, our primary focus is on improving the fluid behavior of hydrogel precursor solutions. In this work, we introduce a method to achieve paste-like hydrogel precursor solutions by combining hyaluronic acid nanoparticles with traditional crosslinked hyaluronic acid hydrogels. Prior to crosslinking, the samples underwent rheological testing to assess yield stress and recovery using linear hyaluronic acid as a control. The experimental groups containing nanoparticles were the only solutions that exhibited a yield stress, demonstrating that the nanoparticulate rather than the linear form of hyaluronic acid was necessary to achieve paste-like behavior. The gels were also photocrosslinked and further characterized as solids, where it was demonstrated that the inclusion of nanoparticles did not adversely affect the compressive modulus and that encapsulated bone marrow-derived mesenchymal stem cells remained viable. Overall, this nanoparticle-based approach provides a platform hydrogel system that exhibits a yield stress prior to crosslinking, and can then be crosslinked into a hydrogel that is capable of encapsulating cells that remain viable. This behavior may hold significant impact for hydrogel applications where a paste-like behavior is desired in the hydrogel precursor solution.en_US
dc.publisherSpringer Verlagen_US
dc.rights© Biomedical Engineering Society 2015en_US
dc.subjectColloidal gelen_US
dc.subjectYield stressen_US
dc.subjectHyaluronic aciden_US
dc.subjectNanoparticlesen_US
dc.titleEnabling Surgical Placement of Hydrogels through Achieving Paste-Like Rheological Behavior in Hydrogel Precursor Solutionsen_US
dc.typeArticleen_US
kusw.kuauthorKieweg, Sarah L.
kusw.kuauthorGehrke, Stevin H.
kusw.kuauthorBerkland, Cory J.
kusw.kuauthorDetamore, Michael S.
kusw.kudepartmentBioengineeringen_US
kusw.kudepartmentChemical and Petroleum Engineeringen_US
kusw.kudepartmentMechanical Engineeringen_US
kusw.kudepartmentPharmaceutical Chemistryen_US
dc.identifier.doi10.1007/s10439-015-1277-8en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC4540702en_US
dc.rights.accessrightsopenAccess


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