Hyaluronic acid graft polymers displaying peptide antigen madulate dendritic cell response in vitro

Chittasupho, Chuda; Sestak, Joshua; Shannon, Laura; Siahaan, Teruna J.; Vines, Charlotte M.; Berkland, Cory J.

dc.contributor.author	Chittasupho, Chuda
dc.contributor.author	Sestak, Joshua
dc.contributor.author	Shannon, Laura
dc.contributor.author	Siahaan, Teruna J.
dc.contributor.author	Vines, Charlotte M.
dc.contributor.author	Berkland, Cory J.
dc.date.accessioned	2017-05-09T18:50:35Z
dc.date.available	2017-05-09T18:50:35Z
dc.date.issued	2014-01-06
dc.identifier.citation	Chittasupho, C., Sestak, J., Shannon, L., Siahaan, T. J., Vines, C. M., & Berkland, C. (2014). Hyaluronic acid graft polymers displaying peptide antigen modulate dendritic cell response in vitro. Molecular Pharmaceutics, 11(1), 367–373. http://doi.org/10.1021/mp4003909	en_US
dc.identifier.uri	http://hdl.handle.net/1808/24051
dc.description.abstract	A novel oxime grafting scheme was utilized to conjugate an ICAM-1 ligand (LABL), a cellular antigen ovalbumin (OVA), or both peptides simultaneously to hyaluronic acid (HA). Samples of HA only and the various peptide grafted HA were found to bind to dendritic cells (DCs). HA with grafted LABL and OVA showed the greatest binding to DCs. Dendritic cells treated with HA, HA with grafted LABL, or HA with grafted LABL and OVA, significantly suppressed T cell and DC conjugate formation, T cell proliferation and reduced proinflammatory cytokine production compared to untreated cells. These results suggest that HA serves as an effective backbone for multivalent ligand presentation for inhibiting T cell response to antigen presentation. In addition, multivalent display of both antigen and an ICAM-1inhibitor (LABL) may enhance binding to DCs and could potentially disrupt cellular signaling leading to autoimmunity.	en_US
dc.publisher	American Chemical Society	en_US
dc.rights	This document is the Accepted Manuscript version of a Published Work that appeared in final form in Molecular Pharmaceutics, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://doi.org/10.1021/mp4003909.	en_US
dc.subject	Peptides	en_US
dc.subject	Hyaluronic acid	en_US
dc.subject	Targeted delivery	en_US
dc.subject	Dendritic cells	en_US
dc.subject	T cells	en_US
dc.title	Hyaluronic acid graft polymers displaying peptide antigen madulate dendritic cell response in vitro	en_US
dc.type	Article	en_US
kusw.kuauthor	Sestak, Joshua
kusw.kuauthor	Siahaan, Teruna J.
kusw.kuauthor	Berkland, Cory J.
kusw.kudepartment	Pharmaceutical Chemistry	en_US
kusw.kudepartment	Petroleum Engineering	en_US
dc.identifier.doi	10.1021/mp4003909	en_US
kusw.oaversion	Scholarly/refereed, author accepted manuscript	en_US
kusw.oapolicy	This item meets KU Open Access policy criteria.	en_US
dc.identifier.pmid	PMC3927369	en_US
dc.rights.accessrights	openAccess

Files in this item

Name:: Sestak_2014.pdf
Size:: 2.257Mb
Format:: PDF

View/Open

This item appears in the following Collection(s)

The University of Kansas prohibits discrimination on the basis of race, color, ethnicity, religion, sex, national origin, age, ancestry, disability, status as a veteran, sexual orientation, marital status, parental status, gender identity, gender expression and genetic information in the University’s programs and activities. The following person has been designated to handle inquiries regarding the non-discrimination policies: Director of the Office of Institutional Opportunity and Access, IOA@ku.edu, 1246 W. Campus Road, Room 153A, Lawrence, KS, 66045, (785)864-6414, 711 TTY.