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    Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism

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    Hamilton_2015.pdf (4.844Mb)
    Issue Date
    2015-01-08
    Author
    Cuskin, Fiona
    Lowe, Elisabeth C.
    Temple, Max J.
    Zhu, Yanping
    Cameron, Elizabeth
    Pudlo, Nicholas A.
    Porter, Nathan T.
    Urs, Karthik
    Thompson, Andrew J.
    Cartmell, Alan
    Rogowski, Artur
    Hamilton, Brian S.
    Chen, Rui
    Tolbert, Thomas J.
    Publisher
    Nature Publishing Group
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
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    Abstract
    Yeasts, which have been a component of the human diet for at least 7000 years, possess an elaborate cell wall α-mannan. The influence of yeast mannan on the ecology of the human microbiota is unknown. Here we show that yeast α-mannan is a viable food source for Bacteroides thetaiotaomicron (Bt), a dominant member of the microbiota. Detailed biochemical analysis and targeted gene disruption studies support a model whereby limited cleavage of α-mannan on the surface generates large oligosaccharides that are subsequently depolymerized to mannose by the action of periplasmic enzymes. Co-culturing studies showed that metabolism of yeast mannan by Bt presents a ‘selfish’ model for the catabolism of this recalcitrant polysaccharide. This report shows how a cohort of highly successful members of the microbiota has evolved to consume sterically-restricted yeast glycans, an adaptation that may reflect the incorporation of eukaryotic microorganisms into the human diet.
    URI
    http://hdl.handle.net/1808/23829
    DOI
    https://doi.org/10.1038/nature13995
    Collections
    • Pharmaceutical Chemistry Scholarly Works [343]
    Citation
    Cuskin, F., Lowe, E. C., Temple, M. J., Zhu, Y., Cameron, E., Pudlo, N. A., … Gilbert, H. J. (2015). Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism. Nature, 517(7533), 165–169. http://doi.org/10.1038/nature13995

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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