dc.contributor.author | Cuskin, Fiona | |
dc.contributor.author | Lowe, Elisabeth C. | |
dc.contributor.author | Temple, Max J. | |
dc.contributor.author | Zhu, Yanping | |
dc.contributor.author | Cameron, Elizabeth | |
dc.contributor.author | Pudlo, Nicholas A. | |
dc.contributor.author | Porter, Nathan T. | |
dc.contributor.author | Urs, Karthik | |
dc.contributor.author | Thompson, Andrew J. | |
dc.contributor.author | Cartmell, Alan | |
dc.contributor.author | Rogowski, Artur | |
dc.contributor.author | Hamilton, Brian S. | |
dc.contributor.author | Chen, Rui | |
dc.contributor.author | Tolbert, Thomas J. | |
dc.date.accessioned | 2017-04-27T16:17:28Z | |
dc.date.available | 2017-04-27T16:17:28Z | |
dc.date.issued | 2015-01-08 | |
dc.identifier.citation | Cuskin, F., Lowe, E. C., Temple, M. J., Zhu, Y., Cameron, E., Pudlo, N. A., … Gilbert, H. J. (2015). Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism. Nature, 517(7533), 165–169. http://doi.org/10.1038/nature13995 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/23829 | |
dc.description.abstract | Yeasts, which have been a component of the human diet for at least 7000 years, possess an elaborate cell wall α-mannan. The influence of yeast mannan on the ecology of the human microbiota is unknown. Here we show that yeast α-mannan is a viable food source for Bacteroides thetaiotaomicron (Bt), a dominant member of the microbiota. Detailed biochemical analysis and targeted gene disruption studies support a model whereby limited cleavage of α-mannan on the surface generates large oligosaccharides that are subsequently depolymerized to mannose by the action of periplasmic enzymes. Co-culturing studies showed that metabolism of yeast mannan by Bt presents a ‘selfish’ model for the catabolism of this recalcitrant polysaccharide. This report shows how a cohort of highly successful members of the microbiota has evolved to consume sterically-restricted yeast glycans, an adaptation that may reflect the incorporation of eukaryotic microorganisms into the human diet. | en_US |
dc.publisher | Nature Publishing Group | en_US |
dc.title | Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Hamilton, Brian S. | |
kusw.kuauthor | Chen, Rui | |
kusw.kuauthor | Tolbert, Thomas J. | |
kusw.kudepartment | Pharmaceutical Chemistry | en_US |
dc.identifier.doi | 10.1038/nature13995 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC4978465 | en_US |
dc.rights.accessrights | openAccess | |