dc.contributor.author | Aksenov, Alexander V. | |
dc.contributor.author | Smirnov, Alexander N. | |
dc.contributor.author | Magedov, Igor V. | |
dc.contributor.author | Reisenauer, Mary R. | |
dc.contributor.author | Aksenov, Nicolai A. | |
dc.contributor.author | Aksenova, Inna V. | |
dc.contributor.author | Pendleton, Alexander L. | |
dc.contributor.author | Nguyen, Gina | |
dc.contributor.author | Johnston, Robert K. | |
dc.contributor.author | Rubin, Michael | |
dc.contributor.author | De Carvalho, Annelise | |
dc.contributor.author | Kiss, Robert | |
dc.contributor.author | Mathieu, Véronique | |
dc.contributor.author | Lefranc, Florence | |
dc.contributor.author | Correa, Jaime | |
dc.contributor.author | Cavazos, David A. | |
dc.contributor.author | Brenner, Andrew J. | |
dc.contributor.author | Bryan, Brad A. | |
dc.contributor.author | Rogelj, Snezna | |
dc.contributor.author | Kornienko, Alexander | |
dc.contributor.author | Frolova, Liliya V. | |
dc.date.accessioned | 2017-04-18T17:31:19Z | |
dc.date.available | 2017-04-18T17:31:19Z | |
dc.date.issued | 2015-03-12 | |
dc.identifier.citation | Aksenov, A. V., Smirnov, A. N., Magedov, I. V., Reisenauer, M. R., Aksenov, N. A., Aksenova, I. V., … Frolova, L. V. (2015). Activity of 2-Aryl-2-(3-indolyl)acetohydroxamates Against Drug-Resistant Cancer Cells. Journal of Medicinal Chemistry, 58(5), 2206–2220. http://doi.org/10.1021/jm501518y | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/23727 | |
dc.description.abstract | Many types of tumor, including glioma, melanoma, non-small cell lung, esophageal, head and neck cancer, among others, are intrinsically resistant to apoptosis induction and poorly responsive to current therapies with proapoptotic agents. In addition, tumors often develop multi-drug resistance based on the cellular efflux of chemotherapeutic agents. Thus, novel anticancer agents capable of overcoming these intrinsic or developed tumor resistance mechanisms are urgently needed. We describe a series of 2-aryl-2-(3-indolyl)acetohydroxamic acids, which are active against apoptosis- and multidrug-resistant cancer cells as well as glioblastoma neurosphere stem-like cell cultures derived from patients. Thus, the described compounds serve as a novel chemical scaffold for the development of potentially highly effective clinical cancer drugs. | en_US |
dc.publisher | American Chemical Society | en_US |
dc.rights | This document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of Medicinal Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/jm501518y. | en_US |
dc.title | Activity of 2-Aryl-2-(3-indolyl)acetohydroxamates Against Drug-Resistant Cancer Cells | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Rubin, Michael | |
kusw.kudepartment | Chemistry | en_US |
dc.identifier.doi | 10.1021/jm501518y | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-1668-9311 | |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess | |