Activity of 2-Aryl-2-(3-indolyl)acetohydroxamates Against Drug-Resistant Cancer Cells

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Issue Date
2015-03-12Author
Aksenov, Alexander V.
Smirnov, Alexander N.
Magedov, Igor V.
Reisenauer, Mary R.
Aksenov, Nicolai A.
Aksenova, Inna V.
Pendleton, Alexander L.
Nguyen, Gina
Johnston, Robert K.
Rubin, Michael
De Carvalho, Annelise
Kiss, Robert
Mathieu, Véronique
Lefranc, Florence
Correa, Jaime
Cavazos, David A.
Brenner, Andrew J.
Bryan, Brad A.
Rogelj, Snezna
Kornienko, Alexander
Frolova, Liliya V.
Publisher
American Chemical Society
Type
Article
Article Version
Scholarly/refereed, author accepted manuscript
Rights
This document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of Medicinal Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/jm501518y.
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Show full item recordAbstract
Many types of tumor, including glioma, melanoma, non-small cell lung, esophageal, head and neck cancer, among others, are intrinsically resistant to apoptosis induction and poorly responsive to current therapies with proapoptotic agents. In addition, tumors often develop multi-drug resistance based on the cellular efflux of chemotherapeutic agents. Thus, novel anticancer agents capable of overcoming these intrinsic or developed tumor resistance mechanisms are urgently needed. We describe a series of 2-aryl-2-(3-indolyl)acetohydroxamic acids, which are active against apoptosis- and multidrug-resistant cancer cells as well as glioblastoma neurosphere stem-like cell cultures derived from patients. Thus, the described compounds serve as a novel chemical scaffold for the development of potentially highly effective clinical cancer drugs.
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Citation
Aksenov, A. V., Smirnov, A. N., Magedov, I. V., Reisenauer, M. R., Aksenov, N. A., Aksenova, I. V., … Frolova, L. V. (2015). Activity of 2-Aryl-2-(3-indolyl)acetohydroxamates Against Drug-Resistant Cancer Cells. Journal of Medicinal Chemistry, 58(5), 2206–2220. http://doi.org/10.1021/jm501518y
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