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HSV-1 strain McKrae is more neuroinvasive than HSV-1 KOS after corneal or vaginal inoculation in mice

dc.contributor.authorWang, Hong
dc.contributor.authorDavido, David J.
dc.contributor.authorMorrison, Lynda A.
dc.date.accessioned2017-04-10T20:31:55Z
dc.date.available2017-04-10T20:31:55Z
dc.date.issued2013-01-20
dc.identifier.citationWang, Hong, David J. Davido, and Lynda A. Morrison. “HSV-1 Strain McKrae Is More Neuroinvasive than HSV-1 KOS after Corneal or Vaginal Inoculation in Mice.” Virus research 173.2 (2013): 436–440.en_US
dc.identifier.urihttp://hdl.handle.net/1808/23619
dc.description.abstractStrains of HSV-1 have been noted to vary in their pathogenesis. We compared the replication of strains KOS and McKrae in mice by two routes of infection, ocular and vaginal. Peripheral replication of KOS was similar (cornea) or attenuated over time (vagina) compared with McKrae; however, McKrae replicated in the nervous system to significantly higher levels than KOS after inoculation by either route. Host genetic background strongly influenced the capacity for virus entry into the nervous system from the vagina. KOS and McKrae replicated equivalently after intracranial inoculation, indicating that McKrae’s pathogenic phenotype is linked to neuroinvasiveness rather than neurovirulence.en_US
dc.publisherElsevieren_US
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subjectHerpes simplex virusen_US
dc.subjectPathogenesisen_US
dc.subjectCorneaen_US
dc.subjectVaginaen_US
dc.subjectCentral nervous systemen_US
dc.subjectMiceen_US
dc.titleHSV-1 strain McKrae is more neuroinvasive than HSV-1 KOS after corneal or vaginal inoculation in miceen_US
dc.typeArticleen_US
kusw.kuauthorDavido, David J.
kusw.kudepartmentMolecular Biosciencesen_US
dc.identifier.doi10.1016/j.virusres.2013.01.001en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.rights.accessrightsopenAccess


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This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Except where otherwise noted, this item's license is described as: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.