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Deferiprone modulates in vitro responses by peripheral blood T cells from control and relapsing remitting multiple sclerosis subjects
dc.contributor.author | Sweeney, Matthew E. | |
dc.contributor.author | Slusser, Joyce G. | |
dc.contributor.author | Lynch, Sharon G. | |
dc.contributor.author | Benedict, Stephen H. | |
dc.contributor.author | Garcia, Sharon L. | |
dc.contributor.author | Rues, Laura | |
dc.contributor.author | LeVine, Steven M. | |
dc.date.accessioned | 2017-03-14T19:57:42Z | |
dc.date.available | 2017-03-14T19:57:42Z | |
dc.date.issued | 2012-11-01 | |
dc.identifier.citation | Sweeney, Matthew E., Joyce G. Slusser, Sharon G. Lynch, Stephen H. Benedict, Sharon L. Garcia, Laura Rues, and Steven M. Levine. "Deferiprone Modulates in Vitro Responses by Peripheral Blood T Cells from Control and Relapsing Remitting Multiple Sclerosis Subjects." International Immunopharmacology 11.11 (2011): 1796-801. | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/23406 | |
dc.description.abstract | T cells are important mediators of autoimmune inflammation in relapsing remitting multiple sclerosis (RRMS). Previous studies found that deferiprone, an iron chelator, suppressed disease activity in a mouse model of multiple sclerosis, and inhibition of T cell proliferation was implicated as a putative mechanism. The objective of the present study was to examine the effects of deferiprone on suppressing in vitro responses of T cells from control and RRMS subjects. Peripheral blood T cells were co-stimulated with anti-CD3 + anti-CD28 and cultured with or without interleukin 2 (IL-2). Proliferating CD4+ T cells from control and RRMS subjects, cultured with or without IL-2, decreased in response to 75 μM deferiprone, although the extent of decreased proliferation of CD4+ T cells from RRMS subjects was less than for control subjects. Proliferating CD8+ T cells from control subjects, cultured with or without IL-2, also decreased in response to 75 μM deferiprone, and this decrease was seen in proliferating CD8+ T cells from RRMS cultured with IL-2. CD4+CD25+ and CD8+CD25+ cells from control subjects, cultured with or without IL-2, declined in 75 M deferiprone, but the decrease was smaller than for the CD4+ and CD8+ proliferative responses. CD4+CD25+ and CD8+CD25+ cells from RRMS subjects showed more variability than for control subjects, but CD4+CD25+ cultured with IL-2 and CD8+CD25+ cells cultured without IL-2 significantly declined in 75 μM deferiprone. CD4+FoxP3+ and CD4+CD25+FoxP3+ cells tended to remain constant or increase. In summary, deferiprone induced declines in proliferative responses at a dosage that is within peak serum pharmacological concentrations. | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | |
dc.subject | CD4 T cells | en_US |
dc.subject | CD8 T cells | en_US |
dc.subject | Regulatory T cells | en_US |
dc.subject | T cell proliferation | en_US |
dc.subject | Multiple sclerosis | en_US |
dc.subject | Deferiprone | en_US |
dc.title | Deferiprone modulates in vitro responses by peripheral blood T cells from control and relapsing remitting multiple sclerosis subjects | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Benedict, Stephen H. | |
kusw.kudepartment | Molecular Biosciences | en_US |
dc.identifier.doi | 10.1016/j.intimp.2011.07.007 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess |
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Except where otherwise noted, this item's license is described as: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.