dc.contributor.author | Phongpradist, Rungsinee | |
dc.contributor.author | Chittasupho, Chuda | |
dc.contributor.author | Okonogi, Siriporn | |
dc.contributor.author | Siahaan, Teruna J. | |
dc.contributor.author | Anuchapreeda, Songyot | |
dc.contributor.author | Ampasavate, Chadarat | |
dc.contributor.author | Berkland, Cory J. | |
dc.date.accessioned | 2017-03-01T20:57:09Z | |
dc.date.available | 2017-03-01T20:57:09Z | |
dc.date.issued | 2014-10-23 | |
dc.identifier.citation | Phongpradist, Rungsinee, Chuda Chittasupho, Siriporn Okonogi, Teruna Siahaan, Songyot Anuchapreeda, Chadarat Ampasavate, and Cory Berkland. "LFA-1 on Leukemic Cells as a Target for Therapy or Drug Delivery." Current Pharmaceutical Design 16.21 (2010): 2321-330. | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/23320 | |
dc.description.abstract | Leukemia therapeutics are aiming for improved efficacy by targeting molecular markers differentially expressed on cancerous cells. Lymphocyte function-associated antigen-1 (LFA-1) expression on various types of leukemia has been well studied. Here, the role and expression of LFA-1 on leukemic cells and the possibility of using this integrin as a target for drug delivery is reviewed. To support this rationale, experimental results were also included where cIBR, a cyclic peptide derived from a binding site of LFA-1, was conjugated to the surface of polymeric nanoparticles and used as a targeting ligand. These studies revealed a correlation of LFA-1 expression level on leukemic cell lines and binding and internalization of cIBR-NPs suggesting a differential binding and internalization of cIBR-NPs to leukemic cells overexpressing LFA-1. Nanoparticles conjugated with a cyclic peptide against an accessible molecular marker of disease hold promise as a selective drug delivery system for leukemia treatment. | en_US |
dc.publisher | Bentham Science Publishers | en_US |
dc.subject | HL-60 cell line | en_US |
dc.subject | LFA-1 | en_US |
dc.subject | Leukemia | en_US |
dc.subject | Molt-3 cell line | en_US |
dc.subject | Molt-4 cell line | en_US |
dc.subject | Peptide | en_US |
dc.subject | Nanoparticles | en_US |
dc.subject | Targeting | en_US |
dc.subject | U937 cell line | en_US |
dc.title | LFA-1 on Leukemic Cells as a Target for Therapy or Drug Delivery | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Berkland, Cory | |
kusw.kudepartment | Pharmaceutical Chemistry | en_US |
dc.identifier.doi | 10.2174/138161210791920450 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess | |