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dc.contributor.authorPhongpradist, Rungsinee
dc.contributor.authorChittasupho, Chuda
dc.contributor.authorOkonogi, Siriporn
dc.contributor.authorSiahaan, Teruna J.
dc.contributor.authorAnuchapreeda, Songyot
dc.contributor.authorAmpasavate, Chadarat
dc.contributor.authorBerkland, Cory J.
dc.date.accessioned2017-03-01T20:57:09Z
dc.date.available2017-03-01T20:57:09Z
dc.date.issued2014-10-23
dc.identifier.citationPhongpradist, Rungsinee, Chuda Chittasupho, Siriporn Okonogi, Teruna Siahaan, Songyot Anuchapreeda, Chadarat Ampasavate, and Cory Berkland. "LFA-1 on Leukemic Cells as a Target for Therapy or Drug Delivery." Current Pharmaceutical Design 16.21 (2010): 2321-330.en_US
dc.identifier.urihttp://hdl.handle.net/1808/23320
dc.description.abstractLeukemia therapeutics are aiming for improved efficacy by targeting molecular markers differentially expressed on cancerous cells. Lymphocyte function-associated antigen-1 (LFA-1) expression on various types of leukemia has been well studied. Here, the role and expression of LFA-1 on leukemic cells and the possibility of using this integrin as a target for drug delivery is reviewed. To support this rationale, experimental results were also included where cIBR, a cyclic peptide derived from a binding site of LFA-1, was conjugated to the surface of polymeric nanoparticles and used as a targeting ligand. These studies revealed a correlation of LFA-1 expression level on leukemic cell lines and binding and internalization of cIBR-NPs suggesting a differential binding and internalization of cIBR-NPs to leukemic cells overexpressing LFA-1. Nanoparticles conjugated with a cyclic peptide against an accessible molecular marker of disease hold promise as a selective drug delivery system for leukemia treatment.en_US
dc.publisherBentham Science Publishersen_US
dc.subjectHL-60 cell lineen_US
dc.subjectLFA-1en_US
dc.subjectLeukemiaen_US
dc.subjectMolt-3 cell lineen_US
dc.subjectMolt-4 cell lineen_US
dc.subjectPeptideen_US
dc.subjectNanoparticlesen_US
dc.subjectTargetingen_US
dc.subjectU937 cell lineen_US
dc.titleLFA-1 on Leukemic Cells as a Target for Therapy or Drug Deliveryen_US
dc.typeArticleen_US
kusw.kuauthorBerkland, Cory
kusw.kudepartmentPharmaceutical Chemistryen_US
dc.identifier.doi10.2174/138161210791920450 en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.rights.accessrightsopenAccess


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