Choice of resident costimulatory molecule can influence cell fate in human naïve CD4+ T cell differentiation
dc.contributor.author | Williams, Kelli M. | |
dc.contributor.author | Dotson, Abby L. | |
dc.contributor.author | Otto, Amber R. | |
dc.contributor.author | Kohlmeier, Jacob E. | |
dc.contributor.author | Benedict, Stephen H. | |
dc.date.accessioned | 2017-02-20T21:58:00Z | |
dc.date.available | 2017-02-20T21:58:00Z | |
dc.date.issued | 2011-08-27 | |
dc.identifier.citation | Williams, Kelli M., Abby L. Dotson, Amber R. Otto, Jacob E. Kohlmeier, and Stephen H. Benedict. "Choice of Resident Costimulatory Molecule Can Influence Cell Fate in Human Naïve CD4 T Cell Differentiation." Cellular Immunology 271.2 (2011): 418-27. | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/23204 | |
dc.description.abstract | With antigen stimulation, naïve CD4+ T cells differentiate to several effector or memory cell populations, and cytokines contribute to differentiation outcome. Several proteins on these cells receive costimulatory signals, but a systematic comparison of their differential effects on naïve T cell differentiation has not been conducted. Two costimulatory proteins, CD28 and ICAM-1, resident on human naïve CD4+ T cells were compared for participation in differentiation. Under controlled conditions, and with no added cytokines, costimulation through either CD3+CD28 or CD3+ICAM-1 induced differentiation to T effector and T memory cells. In contrast, costimulation through CD3+ICAM-1 induced differentiation to Treg cells whereas costimulation through CD3+CD28 did not. | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | |
dc.subject | Costimulation | en_US |
dc.subject | Naive T cell differentiation | en_US |
dc.subject | Regulatory T cells | en_US |
dc.subject | ICAM-1 | en_US |
dc.subject | CD28 | en_US |
dc.subject | Foxp3 | en_US |
dc.title | Choice of resident costimulatory molecule can influence cell fate in human naïve CD4+ T cell differentiation | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Benedict, Stephen H. | |
kusw.kudepartment | Molecular Biosciences | en_US |
dc.identifier.doi | 10.1016/j.cellimm.2011.08.010 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess |
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