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Breaking a pathogen’s iron will: inhibiting siderophore production as an antimicrobial strategy

dc.contributor.authorLamb, Audrey L.
dc.date.accessioned2017-02-01T20:19:47Z
dc.date.available2017-02-01T20:19:47Z
dc.date.issued2015-05-10
dc.identifier.citationLamb, Audrey L. "Breaking a Pathogen's Iron Will: Inhibiting Siderophore Production as an Antimicrobial Strategy." Biochimica Et Biophysica Acta (BBA) - Proteins and Proteomics 1854.8 (2015): 1054-070. Web.en_US
dc.identifier.urihttp://hdl.handle.net/1808/22716
dc.description.abstractThe rise of antibiotic resistance is a growing public health crisis. Novel antimicrobials are sought, preferably developing nontraditional chemical scaffolds that do not inhibit standard targets such as cell wall synthesis or the ribosome. Iron scavenging has been proposed as a viable target, because bacterial and fungal pathogens must overcome the nutritional immunity of the host to be virulent. This review highlights the recent work toward exploiting the biosynthetic enzymes of siderophore production for the design of next generation antimicrobials.en_US
dc.publisherElsevieren_US
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subjectSiderophoreen_US
dc.subjectNonribosomal peptide synthetaseen_US
dc.subjectPolyketide synthaseen_US
dc.subjectNRPS-independent synthetaseen_US
dc.titleBreaking a pathogen’s iron will: inhibiting siderophore production as an antimicrobial strategyen_US
dc.typeArticleen_US
kusw.kuauthorLamb, Audrey L.
kusw.kudepartmentMolecular Biosciencesen_US
dc.identifier.doi10.1016/j.bbapap.2015.05.001en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.rights.accessrightsopenAccess


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This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Except where otherwise noted, this item's license is described as: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.