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Antiproliferative Withanolides from Datura wrightii

dc.contributor.authorZhang, Huaping
dc.contributor.authorBazzill, Joseph
dc.contributor.authorGallagher, Robert J.
dc.contributor.authorSubramanian, Chitra
dc.contributor.authorGrogan, Patrick T.
dc.contributor.authorDay, Victor W.
dc.contributor.authorKindscher, Kelly
dc.contributor.authorCohen, Mark S.
dc.contributor.authorTimmermann, Barbara N.
dc.date.accessioned2017-01-11T19:52:32Z
dc.date.available2017-01-11T19:52:32Z
dc.date.issued2012-12-19
dc.identifier.citationZhang, Huaping, Joseph Bazzill, Robert J. Gallagher, Chitra Subramanian, Patrick T. Grogan, Victor W. Day, Kelly Kindscher, Mark S. Cohen, and Barbara N. Timmermann. "Antiproliferative Withanolides FromDatura Wrightii." Journal of Natural Products 76.3 (2013): 445-49.en_US
dc.identifier.urihttp://hdl.handle.net/1808/22574
dc.description.abstractA new withanolide, named withawrightolide (1), and four known withanolides (2−5) were isolated from the aerial parts of Datura wrightii. The structure of compound 1 was elucidated through 2D NMR and other spectroscopic techniques. In addition, the structure of withametelin L (2) was confirmed by X-ray crystallographic analysis. Using MTS viability assays, withanolides 1−5 showed antiproliferative activities against human glioblastoma (U251 and U87), head and neck squamous cell carcinoma (MDA-1986), and normal fetal lung fibroblast (MRC-5) cells with IC50 values in the range between 0.56 and 5.6 μM.en_US
dc.publisherJournal of Natural Productsen_US
dc.rightsCopyright © 2012 The American Chemical Society and American Society of Pharmacognosyen_US
dc.titleAntiproliferative Withanolides from Datura wrightiien_US
dc.typeArticleen_US
kusw.kuauthorDay, Victor W.
kusw.kudepartmentMSG-Xray Crystallography Laben_US
dc.identifier.doi10.1021/np300766pen_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.rights.accessrightsopenAccess


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