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  • Inactivation of rabbit muscle glycogen phosphorylase b by peroxynitrite revisited: does the nitration of Tyr613 in the allosteric inhibition site control enzymatic function? 

    Sharov, Victor S.; Galeva, Nadezhda A.; Dremina, Elena S.; Williams, Todd D.; Schoneich, Christian (Elsevier, 2008-12-27)
    There is increasing evidence that sequence-specific formation of 3-nitrotyrosine (3-NT) may cause functional changes in target proteins. Recently, the nitration of Tyr residues in glycogen phosphorylase b (Ph-b) was ...
  • LC-MS/MS quantification of salvinorin A from biological fluids 

    Caspers, Michael J.; Williams, Todd D.; Lovell, Kimberly M.; Lozama, Anthony; Butelman, Eduardo R.; Kreek, Mary Jeanne; Johnson, Matthew; Griffiths, Roland; MacLean, Katherine; Prisinzano, Thomas E. (Royal Society of Chemistry, 2014-12-21)
    A facile method for quantifying the concentration of the powerful and widely available hallucinogen salvinorin A (a selective kappa opioid agonist) from non-human primate cerebrospinal fluid (CSF) and human plasma has been ...
  • A Methodology for Simultaneous Fluorogenic Derivatization and Boronate Affinity Enrichment of 3-Nitrotyrosine Containing Peptides 

    Dremina, Elena S.; Li, Xiaobao; Galeva, Nadezhda A.; Sharov, Victor S.; Stobaugh, John F.; Schoneich, Christian (Elsevier Masson, 2012-11-15)
    We synthesized and characterized a new tagging reagent, (3R,4S)-1-(4-(aminomethyl)phenylsulfonyl)pyrrolidine-3,4-diol (APPD), for the selective fluorogenic derivatization of 3-nitrotyrosine (3-NT) residues in peptides ...
  • A label-free mass spectrometry method for the quantification of protein isotypes 

    Winefield, Robert D.; Williams, Todd D.; Himes, Richard H. (Elsevier Masson, 2013-07-15)
    Successful quantitative mass spectrometry (MS) requires strategies to link the mass spectrometer response to the analyte abundance, with the response being dependent on more factors than just analyte abundance. Label-dependent ...
  • Opioid Receptor Probes Derived from Cycloaddition of the Hallucinogen Natural Product Salvinorin A 

    Lozama, Anthony; Cunningham, Christopher W.; Caspers, Michael J.; Douglas, Justin T.; Dersch, Christina M.; Rothman, Richard B.; Prisinzano, Thomas E. (Journal of Natural Products, 2011-02-21)
    As part of our continuing efforts toward more fully understanding the structure−activity relationships of the neoclerodane diterpene salvinorin A, we report the synthesis and biological characterization of unique cycloadducts ...
  • Antiproliferative Withanolides from Datura wrightii 

    Zhang, Huaping; Bazzill, Joseph; Gallagher, Robert J.; Subramanian, Chitra; Grogan, Patrick T.; Day, Victor W.; Kindscher, Kelly; Cohen, Mark S.; Timmermann, Barbara N. (Journal of Natural Products, 2012-12-19)
    A new withanolide, named withawrightolide (1), and four known withanolides (2−5) were isolated from the aerial parts of Datura wrightii. The structure of compound 1 was elucidated through 2D NMR and other spectroscopic ...