Molecular Structures Group
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Recent Submissions
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Antiviral Drug Discovery: Norovirus Proteases and Development of Inhibitors
(MDPI, 2019-02-25)Proteases are a major enzyme group playing important roles in a wide variety of biological processes in life forms ranging from viruses to mammalians. The aberrant activity of proteases can lead to various diseases; ... -
Head-group acylation of monogalactosyldiacylglycerol is a common stress response, and the acyl-galactose acyl composition varies with the plant species and applied stress
(Wiley, 2014-04)Formation of galactose-acylated monogalactosyldiacylglycerols has been shown to be induced by leaf homogenization, mechanical wounding, avirulent bacterial infection, and thawing after snap-freezing. Here, lipidomic analysis ... -
Discrimination of soluble and aggregation-prone proteins based on sequence information
(Royal Society of Chemistry, 2013-04-05)Understanding the factors governing protein solubility is a key to grasp the mechanisms of protein solubility and may provide insight into protein aggregation and misfolding related diseases such as Alzheimer’s disease. ... -
Production, purification, and characterization of recombinant hFSH glycoforms for functional studies
(Elsevier, 2015-04-15)Previously, our laboratory demonstrated the existence of a β-subunit glycosylation-deficient human FSH glycoform, hFSH21. A third variant, hFSH18, has recently been detected in FSH glycoforms isolated from purified pituitary ... -
Constrained TRPV1 agonists synthesized via silver-mediated intramolecular azo-methine ylide cycloaddition of α-iminoamides
(Elsevier, 2014-02-01)As part of an effort to identify agonists of TRPV1, a peripheral sensory nerve ion channel, high throughput screening of the NIH Small Molecule Repository (SMR) collection identified MLS002174161, a pentacyclic benzodiazepine. ... -
Synthesis of a Family of Spirocyclic Scaffolds; Building Blocks for the Exploration of Chemical Space
(American Chemical Society, 2013-07-05)This report describes the preparation of a series of 17 novel racemic spirocyclic scaffolds that are intended for the creation of compound libraries by parallel synthesis for biological screening. Each scaffold features ... -
Inactivation of rabbit muscle glycogen phosphorylase b by peroxynitrite revisited: does the nitration of Tyr613 in the allosteric inhibition site control enzymatic function?
(Elsevier, 2008-12-27)There is increasing evidence that sequence-specific formation of 3-nitrotyrosine (3-NT) may cause functional changes in target proteins. Recently, the nitration of Tyr residues in glycogen phosphorylase b (Ph-b) was ... -
LC-MS/MS quantification of salvinorin A from biological fluids
(Royal Society of Chemistry, 2014-12-21)A facile method for quantifying the concentration of the powerful and widely available hallucinogen salvinorin A (a selective kappa opioid agonist) from non-human primate cerebrospinal fluid (CSF) and human plasma has been ... -
A Methodology for Simultaneous Fluorogenic Derivatization and Boronate Affinity Enrichment of 3-Nitrotyrosine Containing Peptides
(Elsevier Masson, 2012-11-15)We synthesized and characterized a new tagging reagent, (3R,4S)-1-(4-(aminomethyl)phenylsulfonyl)pyrrolidine-3,4-diol (APPD), for the selective fluorogenic derivatization of 3-nitrotyrosine (3-NT) residues in peptides ... -
A label-free mass spectrometry method for the quantification of protein isotypes
(Elsevier Masson, 2013-07-15)Successful quantitative mass spectrometry (MS) requires strategies to link the mass spectrometer response to the analyte abundance, with the response being dependent on more factors than just analyte abundance. Label-dependent ... -
Opioid Receptor Probes Derived from Cycloaddition of the Hallucinogen Natural Product Salvinorin A
(Journal of Natural Products, 2011-02-21)As part of our continuing efforts toward more fully understanding the structure−activity relationships of the neoclerodane diterpene salvinorin A, we report the synthesis and biological characterization of unique cycloadducts ... -
Antiproliferative Withanolides from Datura wrightii
(Journal of Natural Products, 2012-12-19)A new withanolide, named withawrightolide (1), and four known withanolides (2−5) were isolated from the aerial parts of Datura wrightii. The structure of compound 1 was elucidated through 2D NMR and other spectroscopic ...