Antiproliferative Withanolides from Datura wrightii
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Issue Date
2012-12-19Author
Zhang, Huaping
Bazzill, Joseph
Gallagher, Robert J.
Subramanian, Chitra
Grogan, Patrick T.
Day, Victor W.
Kindscher, Kelly
Cohen, Mark S.
Timmermann, Barbara N.
Publisher
Journal of Natural Products
Type
Article
Article Version
Scholarly/refereed, publisher version
Rights
Copyright © 2012 The American Chemical Society and American Society of Pharmacognosy
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Show full item recordAbstract
A new withanolide, named withawrightolide (1), and four known withanolides (2−5) were isolated from the aerial parts of Datura wrightii. The structure of compound 1 was elucidated through 2D NMR and other spectroscopic techniques. In addition, the structure of withametelin L (2) was confirmed by X-ray crystallographic analysis. Using MTS viability assays, withanolides 1−5 showed antiproliferative activities against human glioblastoma (U251 and U87), head and neck squamous cell carcinoma (MDA-1986), and normal fetal lung fibroblast (MRC-5) cells with IC50 values in the range between 0.56 and 5.6 μM.
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Citation
Zhang, Huaping, Joseph Bazzill, Robert J. Gallagher, Chitra Subramanian, Patrick T. Grogan, Victor W. Day, Kelly Kindscher, Mark S. Cohen, and Barbara N. Timmermann. "Antiproliferative Withanolides FromDatura Wrightii." Journal of Natural Products 76.3 (2013): 445-49.
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