dc.contributor.author | Schwieterman, Alicia A. | |
dc.contributor.author | Steves, Alyse N. | |
dc.contributor.author | Yee, Vivian | |
dc.contributor.author | Donelson, Cory J. | |
dc.contributor.author | Pital, Aaron | |
dc.contributor.author | Voyles, Taylor | |
dc.contributor.author | Howard, Austin M. | |
dc.contributor.author | Ereddia, Danielle E. | |
dc.contributor.author | Effrein, Kelsie S. | |
dc.contributor.author | McMurry, Jonathan L. | |
dc.contributor.author | Ackley, Brian D. | |
dc.contributor.author | Chisholm, Andrew D. | |
dc.contributor.author | Hudson, Martin L. | |
dc.date.accessioned | 2016-12-29T18:05:39Z | |
dc.date.available | 2016-12-29T18:05:39Z | |
dc.date.issued | 2015-07-17 | |
dc.identifier.citation | Schwieterman, A. A., Steves, A. N., Yee, V., Donelson, C. J., Pital, A., Voyles, T., … Hudson, M. L. (2015). The C. elegans ephrin EFN-4 functions non-cell autonomously with heparan sulfate proteoglycans to promote axon outgrowth and branching . doi:10.1101/022756 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/22316 | |
dc.description.abstract | The Eph receptors and their cognate ephrin ligands play key roles in many aspects of nervous
system development. These interactions typically occur within an individual tissue type, serving
either to guide axons to their terminal targets or to define boundaries between the rhombomeres
of the hindbrain. We have identified a novel role for the Caenorhabditis elegans ephrin EFN-4 in
promoting primary neurite outgrowth in AIY interneurons and D-class motor neurons. Rescue
experiments reveal that EFN-4 functions non-cell autonomously in the epidermis to promote
primary neurite outgrowth. We also find that EFN-4 plays a role in promoting ectopic axon
branching in a C. elegans model of X-linked Kallmann syndrome. In this context, EFN-4
functions non-cell autonomously in the body wall muscle, and in parallel with HS biosynthesis
genes and HSPG core proteins, which function cell autonomously in the AIY neurons. This is the
first report of an epidermal ephrin providing a developmental cue to the nervous system. | en_US |
dc.rights | The copyright holder for this preprint is the author/funder. It is made available under a CC-BY-NC-ND 4.0 International license. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
dc.title | The C. elegans ephrin EFN-4 functions non-cell autonomously with heparan sulfate proteoglycans to promote axon outgrowth and branching | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Effrein, Kelsie S. | |
kusw.kuauthor | Ackley, Brian D. | |
kusw.kudepartment | Molecular Biosciences | en_US |
dc.identifier.doi | 10.1101/022756 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess | |