Show simple item record

dc.contributor.authorMostafa, Heba H.
dc.contributor.authorvan Loben Sels, Jessica M.
dc.contributor.authorDavido, David J.
dc.date.accessioned2016-12-02T20:07:42Z
dc.date.available2016-12-02T20:07:42Z
dc.date.issued2015-05
dc.identifier.citationMostafa HH, van Loben Sels JM, Davido DJ. 2015. Herpes simplex virus 1 upregulates p35, alters CDK-5 localization, and stimulates CDK-5 kinase activity during acute infection in neurons. J Virol 89:5171–5175. doi:10.1128/JVI.00106-15.en_US
dc.identifier.urihttp://hdl.handle.net/1808/22121
dc.description.abstractThe cyclin-dependent kinase 5 (CDK-5) activating protein, p35, is important for acute herpes simplex virus 1 (HSV-1) replication in mice. This report shows that HSV-1 increases p35 levels, changes the primary localization of CDK-5 from the nucleus to the cytoplasm, and enhances CDK-5 activity during lytic or acute infection. Infected neurons also stained positive for the DNA damage response (DDR) marker γH2AX. We propose that CDK-5 is activated by the DDR to protect infected neurons from apoptosis.en_US
dc.publisherAmerican Society for Microbiologyen_US
dc.rightsCopyright © 2015, American Society for Microbiology.en_US
dc.titleHerpes Simplex Virus 1 Upregulates p 35, Alters CDK-5 Localization, and Stimulates CDK-5 Kinase Activity during Acute Infection in Neuronsen_US
dc.typeArticleen_US
kusw.kuauthorMostafa, Heba H.
kusw.kuauthorvan Loben Sels, Jessica M.
kusw.kuauthorDavido, David J.
kusw.kudepartmentMolecular Biosciencesen_US
dc.identifier.doi10.1128/JVI.00106-15en_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.rights.accessrightsopenAccess


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record