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Herpes Simplex Virus 1 Upregulates p 35, Alters CDK-5 Localization, and Stimulates CDK-5 Kinase Activity during Acute Infection in Neurons
dc.contributor.author | Mostafa, Heba H. | |
dc.contributor.author | van Loben Sels, Jessica M. | |
dc.contributor.author | Davido, David J. | |
dc.date.accessioned | 2016-12-02T20:07:42Z | |
dc.date.available | 2016-12-02T20:07:42Z | |
dc.date.issued | 2015-05 | |
dc.identifier.citation | Mostafa HH, van Loben Sels JM, Davido DJ. 2015. Herpes simplex virus 1 upregulates p35, alters CDK-5 localization, and stimulates CDK-5 kinase activity during acute infection in neurons. J Virol 89:5171–5175. doi:10.1128/JVI.00106-15. | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/22121 | |
dc.description.abstract | The cyclin-dependent kinase 5 (CDK-5) activating protein, p35, is important for acute herpes simplex virus 1 (HSV-1) replication in mice. This report shows that HSV-1 increases p35 levels, changes the primary localization of CDK-5 from the nucleus to the cytoplasm, and enhances CDK-5 activity during lytic or acute infection. Infected neurons also stained positive for the DNA damage response (DDR) marker γH2AX. We propose that CDK-5 is activated by the DDR to protect infected neurons from apoptosis. | en_US |
dc.publisher | American Society for Microbiology | en_US |
dc.rights | Copyright © 2015, American Society for Microbiology. | en_US |
dc.title | Herpes Simplex Virus 1 Upregulates p 35, Alters CDK-5 Localization, and Stimulates CDK-5 Kinase Activity during Acute Infection in Neurons | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Mostafa, Heba H. | |
kusw.kuauthor | van Loben Sels, Jessica M. | |
kusw.kuauthor | Davido, David J. | |
kusw.kudepartment | Molecular Biosciences | en_US |
dc.identifier.doi | 10.1128/JVI.00106-15 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess |