1.65 Å resolution structure of the AraC-family transcriptional activator ToxT from Vibrio cholerae
dc.contributor.author | Li, Jiaqin | |
dc.contributor.author | Wehmeyer, Graham | |
dc.contributor.author | Lovell, Scott | |
dc.contributor.author | Battaile, Kevin P. | |
dc.contributor.author | Egan, Susan M. | |
dc.date.accessioned | 2016-12-01T21:22:02Z | |
dc.date.available | 2016-12-01T21:22:02Z | |
dc.date.issued | 2016-08-26 | |
dc.identifier.citation | 1.65 Å resolution structure of the AraC-family transcriptional activator ToxT from Vibrio cholerae Jiaqin Li, Graham Wehmeyer, Scott Lovell, Kevin P. Battaile, Susan M. Egan Acta Crystallogr F Struct Biol Commun. 2016 Sep 1; 72(Pt 9): 726–731. Published online 2016 Aug 26. doi: 10.1107/S2053230X1601298X | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/22110 | |
dc.description.abstract | ToxT is an AraC-family transcriptional activator protein that controls the expression of key virulence factors in Vibrio cholerae, the causative agent of cholera. ToxT directly activates the expression of the genes that encode the toxin-coregulated pilus and cholera toxin, and also positively auto-regulates its own expression from the tcp promoter. The crystal structure of ToxT has previously been solved at 1.9 Å resolution (PDB entry 3gbg). In this study, a crystal structure of ToxT at 1.65 Å resolution with a similar overall structure to the previously determined structure is reported. However, there are distinct differences between the two structures, particularly in the region that extends from Asp101 to Glu110. This region, which can influence ToxT activity but was disordered in the previous structure, can be traced entirely in the current structure. | en_US |
dc.publisher | International Union of Crystallography | en_US |
dc.relation.isversionof | http://scripts.iucr.org/cgi-bin/paper?S2053230X1601298X | en_US |
dc.rights | Copyright © Li et al. 2016 This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | AraC | en_US |
dc.subject | ToxT | en_US |
dc.subject | Vibrio cholerae | en_US |
dc.subject | Crystal structure | en_US |
dc.subject | Palmitoleic acid | en_US |
dc.subject | Pathogenesis | en_US |
dc.title | 1.65 Å resolution structure of the AraC-family transcriptional activator ToxT from Vibrio cholerae | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Wehmeyer, Graham | |
kusw.kudepartment | Molecular Biosciences | en_US |
dc.identifier.doi | 10.1107/S2053230X1601298X | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess |
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This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.