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    Interaction of Shigella flexneri IpaC with Model Membranes Correlates with Effects on Cultured Cells

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    Picking_2000.pdf (677.6Kb)
    Issue Date
    2000-06
    Author
    Tran, Ngoc
    Barnoski Serfis, Alexa
    Osiecki, John C.
    Picking, Wendy Lynn
    Coye, Lisette
    Davis, Rebecca
    Picking, William D.
    Publisher
    American Society for Microbiology
    Type
    Article
    Article Version
    Scholarly/refereed, publisher version
    Published Version
    http://iai.asm.org/content/68/6/3710.full?sid=def13237-1346-4e93-9913-9c36b1ec5cb0
    Rights
    Copyright © 2000, American Society for Microbiology
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    Abstract
    Invasion of enterocytes by Shigella flexneri requires the properly timed release of IpaB and IpaC at the host-pathogen interface; however, only IpaC has been found to possess quantifiable activities in vitro. We demonstrate here that when added to cultured cells, purified IpaC elicits cytoskeletal changes similar to those that occur during Shigella invasion. This IpaC effect may correlate with its ability to interact with model membranes at physiological pH and to promote entry by an ipaC mutant of S. flexneri.
    URI
    http://hdl.handle.net/1808/21322
    Collections
    • Pharmaceutical Chemistry Scholarly Works [327]
    Citation
    Tran, N., Serfis, A. B., Osiecki, J. C., Picking, W. L., Coye, L., Davis, R., & Picking, W. D. (2000). Interaction of Shigella flexneri IpaC with Model Membranes Correlates with Effects on Cultured Cells. Infection and Immunity, 68(6), 3710–3715.

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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