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Association of low-activity MAOA allelic variants with violent crime in incarcerated offenders
dc.contributor.author | Stetler, Dean A. | |
dc.contributor.author | Davis, Chad | |
dc.contributor.author | Leavitt, Kathryn | |
dc.contributor.author | Schriger, Ilana | |
dc.contributor.author | Benson, Katie | |
dc.contributor.author | Bhakta, Samir | |
dc.contributor.author | Wang, Lam Chee | |
dc.contributor.author | Oben, Cynthia | |
dc.contributor.author | Watters, Matthew | |
dc.contributor.author | Haghnegahdar, Tara | |
dc.contributor.author | Bortolato, Marco | |
dc.date.accessioned | 2015-12-01T15:58:46Z | |
dc.date.available | 2015-12-01T15:58:46Z | |
dc.date.issued | 2014-11 | |
dc.identifier.citation | Stetler, Dean A., Chad Davis, Kathryn Leavitt, Ilana Schriger, Katie Benson, Samir Bhakta, Lam Chee Wang, Cynthia Oben, Matthew Watters, Tara Haghnegahdar, and Marco Bortolato. "Association of Low-activity MAOA Allelic Variants with Violent Crime in Incarcerated Offenders." Journal of Psychiatric Research 58 (2014): 69-75. http://dx.doi.org/10.1016/j.jpsychires.2014.07.006 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/19003 | |
dc.description | This is the author's final draft. Copyright 2014 Elsevier | en_US |
dc.description.abstract | The main enzyme for serotonin degradation, monoamine oxidase (MAO) A, has recently emerged as a key biological factor in the predisposition to impulsive aggression. Male carriers of low-activity variants of the main functional polymorphism of the MAOA gene (MAOA-uVNTR) have been shown to exhibit a greater proclivity to engage in violent acts. Thus, we hypothesized that low-activity MAOA-uVNTR alleles may be associated with a higher risk for criminal violence among male offenders. To test this possibility, we analyzed the MAOA-uVNTR variants of violent (n = 49) and non-violent (n = 40) male Caucasian and African-American convicts in a correctional facility. All participants were also tested with the Childhood Trauma Questionnaire (CTQ), Barratt Impulsivity Scale (BIS-11) and Buss-Perry Aggression Questionnaire (BPAQ) to assess their levels of childhood trauma exposure, impulsivity and aggression, respectively. Our results revealed a robust (P < 0.0001) association between low-activity MAOA-uVNTR alleles and violent crime. This association was replicated in the group of Caucasian violent offenders (P < 0.01), but reached only a marginal trend (P = 0.08) in their African American counterparts. While violent crime charges were not associated with CTQ, BIS-11 and BPAQ scores, carriers of low-activity alleles exhibited a mild, yet significant (P < 0.05) increase in BIS-11 total and attentional-impulsiveness scores. In summary, these findings support the role of MAOA gene as a prominent genetic determinant for criminal violence. Further studies are required to confirm these results in larger samples of inmates and evaluate potential interactions between MAOA alleles and environmental vulnerability factors. | en_US |
dc.publisher | Elsevier | en_US |
dc.subject | Monoamine oxidase A | en_US |
dc.subject | Criminal violence | en_US |
dc.subject | Childhood maltreatment | en_US |
dc.subject | Impulsivity | en_US |
dc.subject | Aggression | en_US |
dc.title | Association of low-activity MAOA allelic variants with violent crime in incarcerated offenders | en_US |
dc.type | Article | |
kusw.kuauthor | Stetler, Dean A. | |
kusw.kudepartment | Molecular Biosciences | en_US |
dc.identifier.doi | 10.1016/j.jpsychires.2014.07.006 | |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | |
kusw.oapolicy | This item meets KU Open Access policy criteria. | |
dc.rights.accessrights | openAccess |