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Photoacoustic tomography of small animal brain with a curved array transducer
dc.contributor.author | Yang, Xinmai | |
dc.contributor.author | Maurudis, Anastasios | |
dc.contributor.author | Gamelin, John | |
dc.contributor.author | Aguirre, Andres | |
dc.contributor.author | Zhu, Quing | |
dc.contributor.author | Wang, Lihong V. | |
dc.date.accessioned | 2015-11-30T16:02:35Z | |
dc.date.available | 2015-11-30T16:02:35Z | |
dc.date.issued | 2009-09-16 | |
dc.identifier.citation | Yang, Xinmai, Anastasios Maurudis, John Gamelin, Andres Aguirre, Quing Zhu, and Lihong V. Wang. "Photoacoustic Tomography of Small Animal Brain with a Curved Array Transducer." J. Biomed. Opt. Journal of Biomedical Optics 14.5 (2009): 054007. http://dx.doi.org/10.1117/1.3227035 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/18990 | |
dc.description | This is the published version. Copyright © 2009 Society of Photo-Optical Instrumentation Engineers | en_US |
dc.description.abstract | We present the application of a curved array photoacoustic tomographic imaging system that can provide rapid, high-resolution photoacoustic imaging of small animal brains. The system is optimized to produce a B-mode, 90-deg field-of-view image at sub-200-μm resolution at a frame rate of ∼1frame∕second when a 10-Hz pulse repetition rate laser is employed. By rotating samples, a complete 360-deg scan can be achieved within 15s. In previous work, two-dimensional (2-D) ex vivo mouse brain cortex imaging has been reported. We report three-dimensional (3-D) small animal brain imaging obtained with the curved array system. The results are presented as a series of 2-D cross-sectional images. Besides structural imaging, the blood oxygen saturation of the animal brain cortex is also measured in vivo. In addition, the system can measure the time-resolved relative changes in blood oxygen saturation level in the small animal brain cortex. Last, ultrasonic gel coupling, instead of the previously adopted water coupling, is conveniently used in near-real-time 2-D imaging. | en_US |
dc.publisher | Society of Photo-optical Instrumentation Engineers | en_US |
dc.title | Photoacoustic tomography of small animal brain with a curved array transducer | en_US |
dc.type | Article | |
kusw.kuauthor | Yang, Xinmai | |
kusw.kudepartment | Mechanical Engineering | en_US |
dc.identifier.doi | 10.1117/1.3227035 | |
kusw.oaversion | Scholarly/refereed, publisher version | |
kusw.oapolicy | This item meets KU Open Access policy criteria. | |
dc.rights.accessrights | openAccess |