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    Photoacoustic tomography of small animal brain with a curved array transducer

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    photoacoustic_tomography2009.pdf (403.8Kb)
    Issue Date
    2009-09-16
    Author
    Yang, Xinmai
    Maurudis, Anastasios
    Gamelin, John
    Aguirre, Andres
    Zhu, Quing
    Wang, Lihong V.
    Publisher
    Society of Photo-optical Instrumentation Engineers
    Type
    Article
    Article Version
    Scholarly/refereed, publisher version
    Metadata
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    Abstract
    We present the application of a curved array photoacoustic tomographic imaging system that can provide rapid, high-resolution photoacoustic imaging of small animal brains. The system is optimized to produce a B-mode, 90-deg field-of-view image at sub-200-μm resolution at a frame rate of ∼1frame∕second when a 10-Hz pulse repetition rate laser is employed. By rotating samples, a complete 360-deg scan can be achieved within 15s. In previous work, two-dimensional (2-D) ex vivo mouse brain cortex imaging has been reported. We report three-dimensional (3-D) small animal brain imaging obtained with the curved array system. The results are presented as a series of 2-D cross-sectional images. Besides structural imaging, the blood oxygen saturation of the animal brain cortex is also measured in vivo. In addition, the system can measure the time-resolved relative changes in blood oxygen saturation level in the small animal brain cortex. Last, ultrasonic gel coupling, instead of the previously adopted water coupling, is conveniently used in near-real-time 2-D imaging.
    Description
    This is the published version. Copyright © 2009 Society of Photo-Optical Instrumentation Engineers
    URI
    http://hdl.handle.net/1808/18990
    DOI
    https://doi.org/10.1117/1.3227035
    Collections
    • Bioengineering Scholarly Works [127]
    • Mechanical Engineering Scholarly Works [114]
    Citation
    Yang, Xinmai, Anastasios Maurudis, John Gamelin, Andres Aguirre, Quing Zhu, and Lihong V. Wang. "Photoacoustic Tomography of Small Animal Brain with a Curved Array Transducer." J. Biomed. Opt. Journal of Biomedical Optics 14.5 (2009): 054007. http://dx.doi.org/10.1117/1.3227035

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    KU Libraries
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    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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