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dc.contributor.authorYang, Qiuhong
dc.contributor.authorCui, Huizhong
dc.contributor.authorCai, Shuang
dc.contributor.authorYang, Xinmai
dc.contributor.authorForrest, M. Laird
dc.date.accessioned2015-11-30T15:31:16Z
dc.date.available2015-11-30T15:31:16Z
dc.date.issued2011-10-27
dc.identifier.citationYang, Qiuhong, Huizhong Cui, Shuang Cai, Xinmai Yang, and M. Laird Forrest. "In Vivo Photoacoustic Imaging of Chemotherapy-induced Apoptosis in Squamous Cell Carcinoma Using a Near-infrared Caspase-9 Probe." J. Biomed. Opt. Journal of Biomedical Optics 16.11 (2011): 116026. http://dx.doi.org/10.1117/1.3650240en_US
dc.identifier.urihttp://hdl.handle.net/1808/18988
dc.descriptionThis is the published version. Copyright 2011 Society of Photo-optical Instrumentation Engineers (SPIE)en_US
dc.description.abstractAnti-cancer drugs typically exert their pharmacological effect on tumors by inducing apoptosis, or programmed cell death, within the cancer cells. However, no tools exist in the clinic for detecting apoptosis in real time. Microscopic examination of surgical biopsies and secondary responses, such as morphological changes, are used to verify efficacy of a treatment. Here, we developed a novel near-infrared dye-based imaging probe to directly detect apoptosis with high specificity in cancer cells by utilizing a noninvasive photoacoustic imaging (PAI) technique. Nude mice bearing head and neck tumors received cisplatin chemotherapy (10 mg/kg) and were imaged by PAI after tail vein injection of the contrast agent. In vivo PAI indicated a strong apoptotic response to chemotherapy on the peripheral margins of tumors, whereas untreated controls showed no contrast enhancement by PAI. The apoptotic status of the mouse tumor tissue was verified by immunohistochemical techniques staining for cleaved caspase-3 p11 subunit. The results demonstrated the potential of this imaging probe to guide the evaluation of chemotherapy treatment.en_US
dc.publisherSociety of Photo-optical Instrumentation Engineers (SPIE)en_US
dc.titleIn vivo photoacoustic imaging of chemotherapy-induced apoptosis in squamous cell carcinoma using a near-infrared caspase-9 probeen_US
dc.typeArticle
kusw.kuauthorYang, Xinmai
kusw.kudepartmentMechanical Engineeringen_US
dc.identifier.doi10.1117/1.3650240
dc.identifier.orcidhttps://orcid.org/0000-0001-7658-1647
kusw.oaversionScholarly/refereed, publisher version
kusw.oapolicyThis item meets KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


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