Higuchi Biosciences Center Scholarly Works: Recent submissions
Now showing items 41-56 of 56
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Multi-faced neuroprotectice effects of Ginsenoside Rg1 in an Alzheimer mouse model
(Elsevier, 2011-10-12)There has been no extensive characterization of the effects of Ginsenoside Rg1, a pharmacological active component purified from the nature product ginseng, in an Alzheimer's disease mouse model. The well-characterized ... -
Depressive Symptoms Affect Working Memory in Healthy Older Adult Hispanics
(OMICS International, 2015-09-27)Objectives: Low and middle income nations will experience an unprecedented growth of the elderly population and subsequent increase in age-related neurological disorders. Worldwide prevalence and incidence of all-types of ... -
Accuracy of preimplantation genetic screening (PGS) is compromised by degree of mosaicism of human embryos
(BioMed Central, 2016-09-05)Background To preclude transfer of aneuploid embryos, current preimplantation genetic screening (PGS) usually involves one trophectoderm biopsy at blastocyst stage, assumed to represent embryo ploidy. Whether one such ... -
Crystal Structures of Staphylococcus epidermidis Mevalonate Diphosphate Decarboxylase Bound to Inhibitory Analogs Reveal New Insight into Substrate Binding and Catalysis
(American Society for Biochemistry and Molecular Biology, 2011-05-11)The polyisoprenoid compound undecaprenyl phosphate is required for biosynthesis of cell wall peptidoglycans in Gram-positive bacteria, including pathogenic Enterococcus, Streptococcus, and Staphylococcus spp. In these ... -
Structural and Biochemical Characterization of Chlamydia trachomatis Hypothetical Protein CT263 Supports That Menaquinone Synthesis Occurs through the Futalosine Pathway
(American Society for Biochemistry and Molecular Biology, 2014-09-24)BACKGROUND: Specific pathways and components for respiration in Chlamydia are poorly understood. RESULTS: The C. trachomatis hypothetical protein CT263 crystal structure displays strong structural similarity with ... -
Structure of CT584 from Chlamydia trachomatis refined to 3.05 Å resolution
(International Union of Crystallography, 2013-10-05)Chlamydia trachomatis is a major cause of various diseases, including blinding trachoma and pelvic inflammatory disease, and is the leading reported sexually transmitted bacterial infection worldwide. All pathogenic ... -
Identifying Loci Contributing to Natural Variation in Xenobiotic Resistance in Drosophila
(Public Library of Science, 2015-11)Natural populations exhibit a great deal of interindividual genetic variation in the response to toxins, exemplified by the variable clinical efficacy of pharmaceutical drugs in humans, and the evolution of pesticide ... -
Genetic deficiency of neuronal RAGE protects against AGE-induced synaptic injury
(Nature Publishing Group, 2014-06-12)Synaptic dysfunction and degeneration is an early pathological feature of aging and age-related diseases, including Alzheimer's disease (AD). Aging is associated with increased generation and deposition of advanced glycation ... -
Tumor suppressive microRNA-137 negatively regulates Musashi-1 and colorectal cancer progression
(Impact Journals, 2015-03-30)Stem cell marker, Musashi-1 (MSI1) is over-expressed in many cancer types; however the molecular mechanisms involved in MSI1 over-expression are not well understood. We investigated the microRNA (miRNA) regulation of MSI1 ... -
Atypical Response Regulator ChxR from Chlamydia trachomatis Is Structurally Poised for DNA Binding
(Public Library of Science, 2014-03-19)ChxR is an atypical two-component signal transduction response regulator (RR) of the OmpR/PhoB subfamily encoded by the obligate intracellular bacterial pathogen Chlamydia trachomatis. Despite structural homology within ... -
Integrate the Mitochondrial Genome into the Nuclear Genome
(OMICS International, 2012-03-09)The mitochondrion is not an ideal location for storing genetic information. Evolution has relocated most of the mitochondrial genome to the nucleus. Transferring all remaining mitochondrial DNA to the nucleus might be an ... -
Broad-Spectrum Antivirals against 3C or 3C-Like Proteases of Picornaviruses, Noroviruses, and Coronaviruses
(American Society for Microbology, 2012-08-22)Phylogenetic analysis has demonstrated that some positive-sense RNA viruses can be classified into the picornavirus-like supercluster, which includes picornaviruses, caliciviruses, and coronaviruses. These viruses possess ... -
An osmium nitrido complex as a π-acid ligand for late transition metals
(Royal Society of Chemistry, 1998)The Os(VI) nitrido complex, TpOs(N)Cl2 (1), acts as a π-acid ligand in the cobalt and platinum complexes CpCo[NOs(Tp)Cl2]2 (2) and (Me2S)Cl2Pt–N[triple bond, length half m-dash]Os(Tp)Cl2 (3). -
The plug-based nanovolume Microcapillary Protein Crystallization System (MPCS)
(International Union of Crystallography, 2008)The Microcapillary Protein Crystallization System (MPCS) embodies a new semi-automated plug-based crystallization technology which enables nanolitre-volume screening of crystallization conditions in a plasticware format ... -
Ecstasy: 3,4-Methylenedioxymethamphetamine (MDMA)
(International Union of Crystallography, 1998-02)The crystal structure of 3,4-methylenedioxymethamphetamine {systematic name: N-methyl-l-[3,4-(methylenedioxy) phenyl]-2-aminopropane } hydrochloride, C 11H 15 - NO2.HC1, also known as 'ecstasy' or MDMA, has been determined ... -
Gene expression patterns in the hippocampus during the development and aging of Glud1 (Glutamate Dehydrogenase 1) transgenic and wild type mice
(BMC Neuroscience, 2014-03-04)BACKGROUND: Extraneuronal levels of the neurotransmitter glutamate in brain rise during aging. This is thought to lead to synaptic dysfunction and neuronal injury or death. To study the effects of glutamate hyperactivity ...