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    Structure of CT584 from Chlamydia trachomatis refined to 3.05 Å resolution

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    BartaM_2013.pdf (1.217Mb)
    Issue Date
    2013-10-05
    Author
    Barta, Michael L.
    Hickey, John M.
    Kemege, Kyle Evan
    Lovell, Scott
    Battaile, Kevin P.
    Hefty, P. Scott
    Publisher
    International Union of Crystallography
    Type
    Article
    Article Version
    Scholarly/refereed, publisher version
    Rights
    Copyright © International Union of Crystallography 2013
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    Abstract
    Chlamydia trachomatis is a major cause of various diseases, including blinding trachoma and pelvic inflammatory disease, and is the leading reported sexually transmitted bacterial infection worldwide. All pathogenic Chlamydiae spp. utilize a supramolecular syringe, or type III secretion system (T3SS), to inject proteins into their obligate host in order to propagate infection. Here, the structure of CT584, a T3SS-associated protein, that has been refined to a resolution of 3.05 Å is reported. The CT584 structure is a hexamer comprised of a trimer of dimers. The structure shares a high degree of similarity to the recently reported structure of an orthologous protein, Cpn0803, from Chlamydia pneumoniae, which highlights the highly conserved nature of this protein across these chlamydial species, despite different tissue tropism and disease pathology.
    URI
    http://hdl.handle.net/1808/21438
    DOI
    https://doi.org/10.1107/S1744309113027371
    Collections
    • Higuchi Biosciences Center Scholarly Works [47]
    Citation
    Barta, M. L., Hickey, J., Kemege, K. E., Lovell, S., Battaile, K. P., & Hefty, P. S. (2013). Structure of CT584 from Chlamydia trachomatis refined to 3.05 Å resolution. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 69(Pt 11), 1196–1201. http://doi.org/10.1107/S1744309113027371

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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