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Research Centers: Recent submissions
Now showing items 181-200 of 241
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Antarctic firn compaction rates from repeat-track airborne radar data: I. Methods
(International Glaciological Society, 2015-10)While measurements of ice-sheet surface elevation change are increasingly used to assess mass change, the processes that control the elevation fluctuations not related to ice-flow dynamics (e.g. firn compaction and ... -
Template-Based Modeling of Protein-RNA Interactions
(Public Library of Science, 2016-09-23)Protein-RNA complexes formed by specific recognition between RNA and RNA-binding proteins play an important role in biological processes. More than a thousand of such proteins in human are curated and many novel RNA-binding ... -
Accuracy of preimplantation genetic screening (PGS) is compromised by degree of mosaicism of human embryos
(BioMed Central, 2016-09-05)Background To preclude transfer of aneuploid embryos, current preimplantation genetic screening (PGS) usually involves one trophectoderm biopsy at blastocyst stage, assumed to represent embryo ploidy. Whether one such ... -
Targeting Epithelial-Mesenchymal Transition for Identification of Inhibitors for Pancreatic Cancer Cell Invasion and Tumor Spheres Formation
(Public Library of Science, 2016-10-20)Background Pancreatic cancer has an enrichment of stem-like cancer cells (CSCs) that contribute to chemoresistant tumors prone to metastasis and recurrence. Drug screening assays based on cytotoxicity cannot identify ... -
River infiltration to a subtropical alluvial aquifer inferred using multiple environmental tracers
(American Geophysical Union, 2015-06-21)Chloride (Cl−), stable isotope ratios of water (δ18O and δ2H), sulfur hexafluoride (SF6), tritium (3H), carbon-14 (14C), noble gases (4He, Ne, and Ar), and hydrometry were used to characterize groundwater-surface water ... -
Spatial Competition: Roughening of an Experimental Interface
(Scientific Reports, 2016-07-28)Limited dispersal distance generates spatial aggregation. Intraspecific interactions are then concentrated within clusters, and between-species interactions occur near cluster boundaries. Spread of a locally dispersing ... -
Mixed Support for Spatial Heterogeneity in Species Interactions: Hummingbirds in a Tropical Disturbance Mosaic
(University of Chicago Press, 1988-01)Many natural landscapes experience frequent disturbance on a small scale. Disturbance loosens or disrupts relations between species, or between species and resources, characteristic of intact communities. One result is the ... -
Crystal Structures of Staphylococcus epidermidis Mevalonate Diphosphate Decarboxylase Bound to Inhibitory Analogs Reveal New Insight into Substrate Binding and Catalysis
(American Society for Biochemistry and Molecular Biology, 2011-05-11)The polyisoprenoid compound undecaprenyl phosphate is required for biosynthesis of cell wall peptidoglycans in Gram-positive bacteria, including pathogenic Enterococcus, Streptococcus, and Staphylococcus spp. In these ... -
Structural and Biochemical Characterization of Chlamydia trachomatis Hypothetical Protein CT263 Supports That Menaquinone Synthesis Occurs through the Futalosine Pathway
(American Society for Biochemistry and Molecular Biology, 2014-09-24)BACKGROUND: Specific pathways and components for respiration in Chlamydia are poorly understood. RESULTS: The C. trachomatis hypothetical protein CT263 crystal structure displays strong structural similarity with ... -
Structure of CT584 from Chlamydia trachomatis refined to 3.05 Å resolution
(International Union of Crystallography, 2013-10-05)Chlamydia trachomatis is a major cause of various diseases, including blinding trachoma and pelvic inflammatory disease, and is the leading reported sexually transmitted bacterial infection worldwide. All pathogenic ... -
The role of interface organizations in science communication and understanding
(Ecological Society of America, 2010-08-01)“Interface” organizations are groups created to foster the use of science in environmental policy, management, and education. Here we compare interface organizations that differ in spatial scale, modes of operation, and ... -
Identifying Loci Contributing to Natural Variation in Xenobiotic Resistance in Drosophila
(Public Library of Science, 2015-11)Natural populations exhibit a great deal of interindividual genetic variation in the response to toxins, exemplified by the variable clinical efficacy of pharmaceutical drugs in humans, and the evolution of pesticide ... -
Genetic deficiency of neuronal RAGE protects against AGE-induced synaptic injury
(Nature Publishing Group, 2014-06-12)Synaptic dysfunction and degeneration is an early pathological feature of aging and age-related diseases, including Alzheimer's disease (AD). Aging is associated with increased generation and deposition of advanced glycation ... -
Tumor suppressive microRNA-137 negatively regulates Musashi-1 and colorectal cancer progression
(Impact Journals, 2015-03-30)Stem cell marker, Musashi-1 (MSI1) is over-expressed in many cancer types; however the molecular mechanisms involved in MSI1 over-expression are not well understood. We investigated the microRNA (miRNA) regulation of MSI1 ... -
Enhancements to the Rosetta Energy Function Enable Improved Identification of Small Molecules that Inhibit Protein-Protein Interactions
(Public Library of Science, 2015-10-20)Protein-protein interactions are among today’s most exciting and promising targets for therapeutic intervention. To date, identifying small-molecules that selectively disrupt these interactions has proven particularly ... -
Chemistry of groundwater discharge inferred from longitudinal river sampling
(American Geophysical Union, 2014-02-22)We present an approach for identifying groundwater discharge chemistry and quantifying spatially distributed groundwater discharge into rivers based on longitudinal synoptic sampling and flow gauging of a river. The method ... -
A Stochastic Analysis of Pumping Tests in Laterally Nonuniform Media
(American Geophysical Union, 1991-09)Conventional pumping test analysis methodology assumes that aquifer transmissivity is invariant in space. The ramifications of this assumption are examined for hypothetical units whose variations in transmissivity are ... -
A modeling tool to evaluate regional coral reef responses to changes in climate and ocean chemistry
(Association for the Sciences of Limnology and Oceanography, 2008-09-03)We developed a spreadsheet-based model for the use of managers, conservationists, and biologists for projecting the effects of climate change on coral reefs at local-to-regional scales. The COMBO (Coral Mortality and ... -
Latent Facies Mapping from Binary Geological Data
(University of Chicago Press, 1991-03)Many geological observation sets contain discrete-state data, which can be encoded as binary patterns. When there are conditional relationships between the variables, latent class analysis may be applied to subdivide the ... -
Ferric oxyhydroxide microparticles in water
(National Institute of Environmental Health Sciences, 1974-12)Mineralogy and specific surface area are major controls on the stabilities of ferric oxyhydroxide microparticles in natural waters. The thermodynamic stabilities of ferric oxyhydroxides, as described by the activity product ...
