A Nitro Enolate Approach to the Synthesis of 4, 5-Disubstituted-2-Aminoimidazoles. Pilot Library Assembly and Screening for Antibiotic and Antibiofilm Activity

Zhaoming, Su; Rogers, Steven A.; McCall, W. Steve; Smith, Alicia C.; Ravishankar, Sindhu; Mullikin, Trey; Melander, Christian

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Issue Date

2010-04-29

Author

Zhaoming, Su

Rogers, Steven A.

McCall, W. Steve

Smith, Alicia C.

Ravishankar, Sindhu

Mullikin, Trey

Melander, Christian

Publisher

Royal Society of Chemistry

Type

Article

Article Version

Scholarly/refereed, publisher version

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Abstract

A library of 4,5-disubstituted-2-aminoimidazoles was synthesized using a nitroenolate route and then screened for antibiofilm and antimicrobial activity. These compounds displayed notable biofilm dispersal and planktonic microbicidal activity against various Gram-positive and Gram-negative bacteria.

Description

This is the published version. Copyright Royal Society of Chemistry

Citation

Su, Zhaoming, Steven A. Rogers, W. Steve Mccall, Alicia C. Smith, Sindhu Ravishankar, Trey Mullikin, and Christian Melander. "A Nitroenolate Approach to the Synthesis of 4,5-disubstituted-2-aminoimidazoles. Pilot Library Assembly and Screening for Antibiotic and Antibiofilm Activity." Organic & Biomolecular Chemistry Org. Biomol. Chem. 8.12 (2010): 2814. DOI:10.1039/C001479F

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