A Nitro Enolate Approach to the Synthesis of 4, 5-Disubstituted-2-Aminoimidazoles. Pilot Library Assembly and Screening for Antibiotic and Antibiofilm Activity

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Issue Date
2010-04-29Author
Zhaoming, Su
Rogers, Steven A.
McCall, W. Steve
Smith, Alicia C.
Ravishankar, Sindhu
Mullikin, Trey
Melander, Christian
Publisher
Royal Society of Chemistry
Type
Article
Article Version
Scholarly/refereed, publisher version
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Show full item recordAbstract
A library of 4,5-disubstituted-2-aminoimidazoles was synthesized using a nitroenolate route and then screened for antibiofilm and antimicrobial activity. These compounds displayed notable biofilm dispersal and planktonic microbicidal activity against various Gram-positive and Gram-negative bacteria.
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This is the published version. Copyright Royal Society of Chemistry
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Citation
Su, Zhaoming, Steven A. Rogers, W. Steve Mccall, Alicia C. Smith, Sindhu Ravishankar, Trey Mullikin, and Christian Melander. "A Nitroenolate Approach to the Synthesis of 4,5-disubstituted-2-aminoimidazoles. Pilot Library Assembly and Screening for Antibiotic and Antibiofilm Activity." Organic & Biomolecular Chemistry Org. Biomol. Chem. 8.12 (2010): 2814. DOI:10.1039/C001479F
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