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dc.contributor.authorLee, Jin Suk
dc.contributor.authorKuroha, Takeshi
dc.contributor.authorHnilova, Marketa
dc.contributor.authorKhatayevich, Dmitriy
dc.contributor.authorKanaoka, Masahiro M.
dc.contributor.authorMcAbee, Jessica M.
dc.contributor.authorSarikaya, Mehmet
dc.contributor.authorTamerler, Candan
dc.identifier.citationLee, J. S., T. Kuroha, M. Hnilova, D. Khatayevich, M. M. Kanaoka, J. M. Mcabee, M. Sarikaya, C. Tamerler, and K. U. Torii. "Direct Interaction of Ligand-receptor Pairs Specifying Stomatal Patterning." Genes & Development 26.2 (2012): 126-36.
dc.descriptionThis is the published version. Copyright © 2012 by Cold Spring Harbor Laboratory Pressen_US
dc.description.abstractValves on the plant epidermis called stomata develop according to positional cues, which likely involve putative ligands (EPIDERMAL PATTERNING FACTORS [EPFs]) and putative receptors (ERECTA family receptor kinases and TOO MANY MOUTHS [TMM]) in Arabidopsis. Here we report the direct, robust, and saturable binding of bioactive EPF peptides to the ERECTA family. In contrast, TMM exhibits negligible binding to EPF1 but binding to EPF2. The ERECTA family forms receptor homomers in vivo. On the other hand, TMM associates with the ERECTA family but not with itself. While ERECTA family receptor kinases exhibit complex redundancy, blocking ERECTA and ERECTA-LIKE1 (ERL1) signaling confers specific insensitivity to EPF2 and EPF1, respectively. Our results place the ERECTA family as the primary receptors for EPFs with TMM as a signal modulator and establish EPF2–ERECTA and EPF1–ERL1 as ligand–receptor pairs specifying two steps of stomatal development: initiation and spacing divisions.en_US
dc.publisherCold Spring Harbor Laboratory Pressen_US
dc.titleDirect interaction of ligand–receptor pairs specifying stomatal patterningen_US
kusw.kuauthorTamerler, Candan
kusw.kudepartmentMechanical Engineeringen_US
kusw.oanotesPer SHERPA/RoMEO, 11/10/15: Author's Pre-print: green tick author can archive pre-print (ie pre-refereeing) Author's Post-print: green tick author can archive post-print (ie final draft post-refereeing) Publisher's Version/PDF: grey tick subject to Restrictions below, author can archive publisher's version/PDF General Conditions:

Author's pre-print on preprint server Author's pre-print must be updated with citation, DOI and link to article upon publication Publisher's version/PDF may be used after 6 months Publisher's version/PDF and Author's post-print on author's personal website, institutional repository, funder's designated repository Authors retain copyright Content automatically sent to PubMed Central after 6 months Publisher copyright and source must be acknowledged
kusw.oaversionScholarly/refereed, publisher version
kusw.oapolicyThis item meets KU Open Access policy criteria.

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