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    Direct interaction of ligand–receptor pairs specifying stomatal patterning

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    Tamerler_direct_interaction2015.pdf (1.459Mb)
    Issue Date
    2012-01-12
    Author
    Lee, Jin Suk
    Kuroha, Takeshi
    Hnilova, Marketa
    Khatayevich, Dmitriy
    Kanaoka, Masahiro M.
    McAbee, Jessica M.
    Sarikaya, Mehmet
    Tamerler, Candan
    Publisher
    Cold Spring Harbor Laboratory Press
    Type
    Article
    Article Version
    Scholarly/refereed, publisher version
    Metadata
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    Abstract
    Valves on the plant epidermis called stomata develop according to positional cues, which likely involve putative ligands (EPIDERMAL PATTERNING FACTORS [EPFs]) and putative receptors (ERECTA family receptor kinases and TOO MANY MOUTHS [TMM]) in Arabidopsis. Here we report the direct, robust, and saturable binding of bioactive EPF peptides to the ERECTA family. In contrast, TMM exhibits negligible binding to EPF1 but binding to EPF2. The ERECTA family forms receptor homomers in vivo. On the other hand, TMM associates with the ERECTA family but not with itself. While ERECTA family receptor kinases exhibit complex redundancy, blocking ERECTA and ERECTA-LIKE1 (ERL1) signaling confers specific insensitivity to EPF2 and EPF1, respectively. Our results place the ERECTA family as the primary receptors for EPFs with TMM as a signal modulator and establish EPF2–ERECTA and EPF1–ERL1 as ligand–receptor pairs specifying two steps of stomatal development: initiation and spacing divisions.
    Description
    This is the published version. Copyright © 2012 by Cold Spring Harbor Laboratory Press
    URI
    http://hdl.handle.net/1808/18872
    DOI
    https://doi.org/10.1101/gad.179895.111
    Collections
    • Bioengineering Program Scholarly Works [144]
    • Mechanical Engineering Scholarly Works [135]
    Citation
    Lee, J. S., T. Kuroha, M. Hnilova, D. Khatayevich, M. M. Kanaoka, J. M. Mcabee, M. Sarikaya, C. Tamerler, and K. U. Torii. "Direct Interaction of Ligand-receptor Pairs Specifying Stomatal Patterning." Genes & Development 26.2 (2012): 126-36. http://dx.doi.org/10.1101/gad.179895.111

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    KU Libraries
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    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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