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    Human umbilical cord mesenchymal stromal cells in regenerative medicine

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    Detamore-umbilical_cord2013.pdf (214.8Kb)
    Issue Date
    2013-11-25
    Author
    Detamore, Michael S.
    Publisher
    BioMed Central
    Type
    Article
    Article Version
    Scholarly/refereed, publisher version
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    Abstract
    Cells of the human umbilical cord offer tremendous potential for improving human health. Cells from the Wharton’s jelly (umbilical cord stroma) in particular, referred to as human umbilical cord mesenchymal stromal cells (HUCMSCs), hold several advantages that make them appealing for translational research. In the previous issue of Stem Cell Research & Therapy, Chon and colleagues made an important contribution to the HUCMSC literature not only by presenting HUCMSCs as an emerging cell source for intervertebral disc regeneration in general and the nucleus pulposus in particular, but also by demonstrating that an extracellular matrix-based strategy might be preferred over the use of growth factors. By culturing HUCMSCs under hypoxia in serum-free conditions in the presence of Matrigel with laminin-111, they were able to achieve intense collagen II staining by 21 days without the addition of exogenous growth factors. There is tremendous translational significance here in that such raw materials may alleviate the need for the use of growth factors in some instances, and this may have important ramifications in reducing product cost and streamlining regulatory approval. Chon and colleagues provide a promising example of the potential of HUCMSCs, demonstrating the ability to guide HUCMSC differentiation even in the absence of serum and growth factors and supporting the use of HUCMSCs as a viable alternative in intervertebral disc regeneration.
    Description
    This is the published version. Copyright © 2013 BioMed Central Ltd.
    URI
    http://hdl.handle.net/1808/18750
    DOI
    https://doi.org/10.1186/scrt353
    Collections
    • Bioengineering Scholarly Works [127]
    • Chemical and Petroleum Engineering Scholarly Works [153]
    Citation
    Detamore, Michael S. "Human Umbilical Cord Mesenchymal Stromal Cells in Regenerative Medicine." Stem Cell Research & Therapy Stem Cell Res Ther 4.6 (2013): 142. http://dx.doi.org/10.1186/scrt353

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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