Oral Probiotic Microcapsule Formulation Ameliorates Non-Alcoholic Fatty Liver Disease in Bio F1B Golden Syrian Hamsters
dc.contributor.author | Bhathena, Jasmine | |
dc.contributor.author | Martoni, Christopher | |
dc.contributor.author | Kulamarva, Arun | |
dc.contributor.author | Tomaro-Duchesneau, Catherine | |
dc.contributor.author | Malhotra, Meenakshi | |
dc.contributor.author | Paul, Arghya | |
dc.contributor.author | Urbanska, Aleksandra Malgorzata | |
dc.contributor.author | Prakash, Satya | |
dc.date.accessioned | 2015-10-14T15:45:42Z | |
dc.date.available | 2015-10-14T15:45:42Z | |
dc.date.issued | 2013-03-12 | |
dc.identifier.citation | Bhathena, Jasmine, Christopher Martoni, Arun Kulamarva, Catherine Tomaro-Duchesneau, Meenakshi Malhotra, Arghya Paul, Aleksandra Malgorzata Urbanska, and Satya Prakash. "Oral Probiotic Microcapsule Formulation Ameliorates Non-Alcoholic Fatty Liver Disease in Bio F1B Golden Syrian Hamsters." PLoS ONE 8.3 (2013). http://dx.doi.org/10.1371/journal.pone.0058394 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/18688 | |
dc.description.abstract | The beneficial effect of a microencapsulated feruloyl esterase producing Lactobacillus fermentum ATCC 11976 formulation for use in non-alcoholic fatty liver disease (NAFLD) was investigated. For which Bio F1B Golden Syrian hamsters were fed a methionine deficient/choline devoid diet to induce non-alcoholic fatty liver disease. Results, for the first time, show significant clinical benefits in experimental animals. Examination of lipids show that concentrations of hepatic free cholesterol, esterified cholesterol, triglycerides and phospholipids were significantly lowered in treated animals. In addition, serum total cholesterol, triglycerides, uric acid and insulin resistance were found to decrease in treated animals. Liver histology evaluations showed reduced fat deposits. Western blot analysis shows significant differences in expression levels of key liver enzymes in treated animals. In conclusion, these findings suggest the excellent potential of using an oral probiotic formulation to ameliorate NAFLD. | en_US |
dc.publisher | Public Library of Science | en_US |
dc.rights | © 2013 Bhathena et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | Oral Probiotic Microcapsule Formulation Ameliorates Non-Alcoholic Fatty Liver Disease in Bio F1B Golden Syrian Hamsters | en_US |
dc.type | Article | |
kusw.kuauthor | Paul, Arghya | |
kusw.kudepartment | Chemical & Petroleum Engr | en_US |
kusw.oanotes | Per SHERPA/RoMEO, 10/14/15: Author's Pre-print: green tick author can archive pre-print (ie pre-refereeing) Author's Post-print: green tick author can archive post-print (ie final draft post-refereeing) Publisher's Version/PDF: green tick author can archive publisher's version/PDF General Conditions: Creative Commons Attribution License Eligible UK authors may deposit in OpenDepot Publisher's version/PDF may be used | en_US |
dc.identifier.doi | 10.1371/journal.pone.0058394 | |
kusw.oaversion | Scholarly/refereed, publisher version | |
kusw.oapolicy | This item meets KU Open Access policy criteria. | |
dc.rights.accessrights | openAccess |
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Except where otherwise noted, this item's license is described as: © 2013 Bhathena et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.