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KU Med Center Dissertations and Theses: Recent submissions
Now showing items 181-200 of 464
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Gestational Weight Gain and Offspring Cognition
(University of Kansas, 2017-05-31)ABSTRACT Background: Two thirds of US women are not gaining the recommended weight during pregnancy (1) and 50% of women giving birth in the US are either overweight or obese (2). While little is known about the effect of ... -
Exploring mechanisms of metastasis suppression in metastatic melaoma
(University of Kansas, 2017-05-31)Melanoma is responsible for 76% of deaths from skin cancer, making it the deadliest form of commonly diagnosed skin cancer. The deadly nature of melanoma is due to its tendency towards rapid, early metastasis. Metastasis, ... -
Exploring the Impact of Activity-Dependent Stimulation on Neuroanatomy
(University of Kansas, 2017-05-31)Background: Activity-dependent stimulation (ADS) uses recorded neural activity to trigger stimulation of the brain. Open-loop stimulation (OLS) is independent of neural feedback, thus relying on a machine-generated pattern ... -
The role of IFITM1 in promoting breast cancer aggression and aromatase-inhibitor resistance
(University of Kansas, 2017-05-31)Breast cancer remains the leading malignancy among women in the United States, affecting an estimated 246,660 women in 2016. Breast cancer can be separated into three groups known as estrogen receptor/ progesterone receptor ... -
Memory: From Sensory Circuits To Protein Conformations
(University of Kansas, 2017-05-31)The ability to form, store, and retrieve memories is an essential capacity of many animals. Only in the past half-century, however, have the key neuronal and molecular events that underlie memory been studied. This has ... -
THE COMPARISON OF TWO PROTOCOLS EXAMINING FOOD VARIETY OF YOUNG CHILDREN (2-8 YEARS) WITH AUTISM SPECTRUM DISORDER
(University of Kansas, 2017-05-31)Autism spectrum disorder, a neurodevelopmental disease that can cause social and behavioral difficulties, is commonly associated with repetitive behaviors. One such behavior is food selectivity. To assess food selectivity, ... -
Snacking During Pregnancy and its Relationship with Gestational Weight Gain
(University of Kansas, 2017-05-31)Background High-fiber diets are associated with weight management though data are lacking in pregnant women. Pregnant women consume half of the daily fiber recommendation (~15 grams/day) and 55% experience excessive ... -
INFLUENCE OF DIET IN ALZHEIMER’S DISEASE: THE ROLE OF CARBOHYDRATE INTAKE AND KETOGENIC THERAPY
(University of Kansas, 2017-08-31)Background: One in every 9 persons age 65 years and older and 1 in every 3 persons age 85 years and older has Alzheimer’s disease. The etiology of the disease is not well understood. For decades, cerebral accumulation of ... -
SYMPTOM OCCURRENCE AND SEVERITY AND HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH BREAST OR GYNECOLOGIC CANCER RECEIVING MATCHED CANCER THERAPY
(University of Kansas, 2017-05-31)Background: Scientific advancements in oncology allow routine patient cancer genomic profiling, which may guide the choice of novel therapies to match genomic alterations for the treatment of cancer. Potential differences ... -
Characterization of SPECC1L function in cell adhesion and migration in craniofacial morphogenesis
(University of Kansas, 2017-05-31)Orofacial clefts are frequent congenital malformations, which can result from reduced contribution of cranial neural crest cells (CNCCs) to the developing cranium. Upon delamination from embryonic neural folds, CNCCs migrate ... -
Children with Autism Wearing Action Cameras: Changing Parent/Child Interactions Using Point-of-View Video Modeling
(University of Kansas, 2017-05-31)Researchers have found that families list interventions targeting the development of social interaction skills among the most sought after treatments for their children with autism spectrum disorder (ASD) (Green et al., ... -
Hepatitis C Virus Suppresses Autophagosome Degradation by Arl8b-mediated Lysosomal Positioning
(University of Kansas, 2016-05-31)HCV infection increases steady-state autophagosome numbers but the mechanism of this effect is poorly understood. Flux assays suggest that an increase in autophagosomes results from a block in the fusion of autophagosomes ... -
The Role of FOXO3 in Mechanisms of Doxorubicin Resistance in Hepatocellular Carcinoma
(University of Kansas, 2016-05-31)Trans-arterial chemoembolization (TACE) with doxorubicin is commonly used to treat hepatocellular carcinoma (HCC), but has limited efficacy due to a high level of resistance. The factors that determine the sensitivity to ... -
INFANT FORMULA WITH LONG CHAIN POLYUNSATURATED FATTY ACID AND CHILDHOOD BLOOD PRESSURE
(University of Kansas, 2017-08-31)Abstract Background: Breastfeeding of term infants has been associated with decreased blood pressure (BP) in later ages compared to formula feeding. The protective effect of human milk against childhood BP has been linked ... -
Incorporating Simulations of the Nutrition-Focused Physical Exam into Graduate-Level Dietetics Curriculum
(University of Kansas, 2017-08-31)Introduction: The nutrition-focused physical exam (NFPE) is an integral component of a nutrition assessment performed by registered dietitians, and is used to identify signs of malnutrition. However, many dietitians are ... -
Novel Restriction of HIV-1 by Chimeric Human APOBEC3A
(University of Kansas, 2017-08-31)The human apolipoprotein B mRNA editing enzyme catalytic peptide-like 3 (APOBEC3; A3) family of proteins are a family of seven cytidine deaminases (A3A, A3B, A3C, A3D, A3F, A3G and A3H) that restrict certain viral infections. ... -
Early Adolescent Perceptions Regarding Sources of Sexual Health Information
(University of Kansas, 2017-08-31)Early adolescence includes youth approximately 11-14 years of age. This age group represents a population open to learning more information about sexuality and signifies a developmental period where effective sexuality ... -
The Role of Endoglin in the Immunomodulatory Capacities of Mesenchymal Stem Cells and the Relationship to Hyperbaric Oxygen Therapy
(University of Kansas, 2017-05-31)Mesenchymal stem cells (MSCs), a type of “adult” stem cell found in most organs, represent an emerging tool in the field of regenerative medicine. In the setting of myocardial injury, for example, MSCs have been shown to ... -
The Histone H3, Lysine 79 Methyltransferase Activity of DOT1L is Necessary for Murine Yolk Sac Erythro-Myeloid Progenitor Self-Renewal and Erythroblast Survival
(University of Kansas, 2017-08-31)Disruptor of Telomere silencing 1-Like (DOT1L), is a histone 3, lysine 79 (H3K79) methyltransferase that has been implicated in multiple processes, including activation of transcription, regulation of the cell cycle, ... -
Studies on developing behavior in Anuran larvae and tadpoles
(University of Kansas, 1937)