KUKU

KU ScholarWorks

  • myKU
  • Email
  • Enroll & Pay
  • KU Directory
    • Login
    View Item 
    •   KU ScholarWorks
    • Dissertations and Theses
    • Dissertations
    • View Item
    •   KU ScholarWorks
    • Dissertations and Theses
    • Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    SYMPTOM OCCURRENCE AND SEVERITY AND HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH BREAST OR GYNECOLOGIC CANCER RECEIVING MATCHED CANCER THERAPY

    Thumbnail
    View/Open
    Williams_ku_0099D_15170_DATA_1.pdf (2.175Mb)
    Issue Date
    2017-05-31
    Author
    Williams, Kirstin Anne
    Publisher
    University of Kansas
    Format
    171 pages
    Type
    Dissertation
    Degree Level
    Ph.D.
    Discipline
    Nursing
    Rights
    Copyright held by the author.
    Metadata
    Show full item record
    Abstract
    Background: Scientific advancements in oncology allow routine patient cancer genomic profiling, which may guide the choice of novel therapies to match genomic alterations for the treatment of cancer. Potential differences in cancer therapy-related symptom severity and occurrence as well as health-related quality of life (HRQOL) between patients who receive matched therapy and those who do not have not been previously explored. Purposes: The purpose of this study was to describe the characteristics of patients with breast or gynecologic cancer who were receiving matched therapy or not matched therapy, as well as to describe their cancer therapy-related symptom occurrence and severity, and overall HRQOL. Methods: Existing data from the records of 129 patients receiving care at a cancer center in the upper Midwest were used for this descriptive correlational research study. Descriptive statistics and multiple linear regression analyses were performed to address the study purpose and aims. Results: This study found that patients receiving matched therapy had lower mean therapy-related symptom checklist (TRSC) scores (M = 14.7) than patients receiving not matched therapy (M = 16.1). Compared to prior studies, a higher percentage of patients (29%) added symptoms to the TRSC. TRSC scores for individual symptoms were similar across groups, except pain, which was higher in patients receiving matched therapy, and hair loss, which was higher in patients receiving not matched therapy. Patients receiving matched therapy had higher mean Health-Related Quality of Life – Linear Analogue Self Assessment (HRQOL-LASA) scores (M = 48.1), than patients receiving not matched therapy (M = 45.4). Patients who had prior therapy less than three months prior to the onset of the current therapy had significantly higher TRSC total scores than patients with no prior therapy (B = 6.2, p = 0.045). Patients who had a higher number of prior lines of therapy had significantly higher HRQOL-LASA scores (B = 0.56, p = 0.05). Patients with higher TRSC scores had significantly lower HRQOL-LASA (B = -0.36, p < 0.001). Conclusions: Patients receiving matched therapy did not have worse therapy-related symptoms or HRQOL. Findings provide initial information about the symptom experience and HRQOL for patients receiving matched therapy.
    URI
    http://hdl.handle.net/1808/25882
    Collections
    • KU Med Center Dissertations and Theses [464]
    • Dissertations [4472]

    Items in KU ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.


    We want to hear from you! Please share your stories about how Open Access to this item benefits YOU.


    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

    Browse

    All of KU ScholarWorksCommunities & CollectionsThis Collection

    My Account

    LoginRegister

    Statistics

    View Usage Statistics

    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

    The University of Kansas
      Contact KU ScholarWorks
    Lawrence, KS | Maps
     
    • Academics
    • Admission
    • Alumni
    • Athletics
    • Campuses
    • Giving
    • Jobs

    The University of Kansas prohibits discrimination on the basis of race, color, ethnicity, religion, sex, national origin, age, ancestry, disability, status as a veteran, sexual orientation, marital status, parental status, gender identity, gender expression and genetic information in the University’s programs and activities. The following person has been designated to handle inquiries regarding the non-discrimination policies: Director of the Office of Institutional Opportunity and Access, IOA@ku.edu, 1246 W. Campus Road, Room 153A, Lawrence, KS, 66045, (785)864-6414, 711 TTY.

     Contact KU
    Lawrence, KS | Maps