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dc.contributor.authorDentler, William L., Jr
dc.date.accessioned2015-03-25T19:47:31Z
dc.date.available2015-03-25T19:47:31Z
dc.date.issued2005-08-15
dc.identifier.citationDentler, W. "Intraflagellar Transport (IFT) during Assembly and Disassembly of Chlamydomonas Flagella." The Journal of Cell Biology 170.4 (2005): 649-59. http://dx.doi.org/10.1083/jcb.200412021.en_US
dc.identifier.urihttp://hdl.handle.net/1808/17216
dc.description.abstractIntraflagellar transport (IFT) of particles along flagellar microtubules is required for the assembly and maintenance of eukaryotic flagella and cilia. In Chlamydomonas, anterograde and retrograde particles viewed by light microscopy average 0.12-μm and 0.06-μm diameter, respectively. Examination of IFT particle structure in growing flagella by electron microscopy revealed similar size aggregates composed of small particles linked to each other and to the membrane and microtubules. To determine the relationship between the number of particles and flagellar length, the rate and frequency of IFT particle movement was measured in nongrowing, growing, and shortening flagella. In all flagella, anterograde and retrograde IFT averaged 1.9 μm/s and 2.7 μm/s, respectively, but retrograde IFT was significantly slower in flagella shorter than 4 μm. The number of flagellar IFT particles was not fixed, but depended on flagellar length. Pauses in IFT particle entry into flagella suggest the presence of a periodic “gate” that permits up to 4 particles/s to enter a flagellum.en_US
dc.publisherThe Rockefeller University Pressen_US
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/
dc.titleIntraflagellar transport (IFT) during assembly and disassembly of Chlamydomonas flagellaen_US
dc.typeArticle
kusw.kuauthorDentler, William
kusw.kudepartmentMolecular Biosciencesen_US
dc.identifier.doi10.1083/jcb.200412021
kusw.oaversionScholarly/refereed, publisher version
kusw.oapolicyThis item does not meet KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.