ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated. If you have any questions, please contact Marianne Reed at .

Show simple item record

dc.contributor.authorDeeds, Eric J.
dc.contributor.authorHennessey, Hooman
dc.contributor.authorShakhnovich, Eugene I.
dc.identifier.citationDeeds, Eric J.; Hennessey, Hooman; Shakhnovich, Eugene I. (2005). "Prokaryotic phylogenies inferred from protein structural domains." Genome Research, 15:393-402.
dc.descriptionThis is the publisher's version, also available electronically from
dc.description.abstractThe determination of the phylogenetic relationships among microorganisms has long relied primarily on gene sequence information. Given that prokaryotic organisms often lack morphological characteristics amenable to phylogenetic analysis, prokaryotic phylogenies, in particular, are often based on sequence data. In this work, we explore a new source of phylogenetic information, the distribution of protein structural domains within fully sequenced prokaryotic genomes. The evolution of the structural domains we use has been studied extensively, allowing us to base our phylogenetic methods on testable theoretical models of structural evolution. We find that the methods that produce reasonable phylogenetic relationships are indeed the methods that are most consistent with theoretical evolutionary models. This work represents, to our knowledge, the first such theoretically motivated phylogeny, as well as the first application of structural information to phylogeny on this scale. Our results have strong implications for the phylogenetic relationships among prokaryotic organisms and for the understanding of protein evolution as a whole.en_US
dc.publisherCold Spring Harbor Laboratory Pressen_US
dc.titleProkaryotic phylogenies inferred from protein structural domainsen_US
kusw.kuauthorDeeds, Eric J.
kusw.kudepartmentMolecular Biosciencesen_US
kusw.oaversionScholarly/refereed, publisher version
kusw.oapolicyThis item does not meet KU Open Access policy criteria.

Files in this item


This item appears in the following Collection(s)

Show simple item record