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Exploring chemical diversity via a modular reaction pairing strategy

dc.contributor.authorLoh, Joanna K.
dc.contributor.authorYoon, Sun Young
dc.contributor.authorRolfe, Alan
dc.contributor.authorNeuenswander, Benjamin
dc.contributor.authorLushington, Gerald H.
dc.contributor.authorHanson, Paul R.
dc.contributor.authorSamarakoon, Thiwanka Bandara
dc.contributor.authorPorubsky, Patrick R.
dc.date.accessioned2014-12-15T20:41:43Z
dc.date.available2014-12-15T20:41:43Z
dc.date.issued2012-08-15
dc.identifier.citationLoh, Joanna K. et al. (2012). "Exploring chemical diversity via a modular reaction pairing strategy." Beilstein Journal of Organic Chemistry, 8:1293-1302. http://www.dx.doi.org/10.3762/bjoc.8.147
dc.identifier.issn1860-5397
dc.identifier.urihttp://hdl.handle.net/1808/16108
dc.descriptionThis is the publisher's version, also available electronically from http://www.beilstein-journals.org/bjoc/single/articleFullText.htm?publicId=1860-5397-8-147.
dc.description.abstractThe efficient synthesis of an 80-member library of unique benzoxathiazocine 1,1-dioxides by a microwave-assisted, intermolecular nucleophilic aromatic substitution (SNAr) diversification pathway is reported. Eight benzofused sultam cores were generated by means of a sulfonylation/SNAr/Mitsunobu reaction pairing protocol, and subsequently diversified by intermolecular SNAr with ten chiral, non-racemic amine/amino alcohol building blocks. Computational analyses were employed to explore and evaluate the chemical diversity of the library
dc.publisherBeilstein-Institut
dc.subject1-dioxides
dc.subjectbenzoxathiazocine 1,1-dioxides
dc.subjectchemical diversity
dc.subjectinformatics
dc.subjectnucleophilic aromatic substitution (SNAr)
dc.subjectsultams
dc.titleExploring chemical diversity via a modular reaction pairing strategy
dc.typeArticle
kusw.kuauthorLoh, Joanna K.
kusw.kuauthorYoon, Sun Young
kusw.kuauthorSamarakoon, Thiwanka Bandara
kusw.kuauthorRolfe, Alan
kusw.kuauthorPorubsky, Patrick R.
kusw.kuauthorNeuenswander, Benjamin
kusw.kuauthorLushington, Gerald H.
kusw.kuauthorHanson, Paul R.
kusw.kudepartmentChemistry
kusw.oastatusfullparticipation
dc.identifier.doi10.3762/bjoc.8.147
kusw.oaversionScholarly/refereed, publisher version
kusw.oapolicyThis item meets KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


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