Exploring chemical diversity via a modular reaction pairing strategy

Loh, Joanna K.; Yoon, Sun Young; Rolfe, Alan; Neuenswander, Benjamin; Lushington, Gerald H.; Hanson, Paul R.; Samarakoon, Thiwanka Bandara; Porubsky, Patrick R.

dc.contributor.author	Loh, Joanna K.
dc.contributor.author	Yoon, Sun Young
dc.contributor.author	Rolfe, Alan
dc.contributor.author	Neuenswander, Benjamin
dc.contributor.author	Lushington, Gerald H.
dc.contributor.author	Hanson, Paul R.
dc.contributor.author	Samarakoon, Thiwanka Bandara
dc.contributor.author	Porubsky, Patrick R.
dc.date.accessioned	2014-12-15T20:41:43Z
dc.date.available	2014-12-15T20:41:43Z
dc.date.issued	2012-08-15
dc.identifier.citation	Loh, Joanna K. et al. (2012). "Exploring chemical diversity via a modular reaction pairing strategy." Beilstein Journal of Organic Chemistry, 8:1293-1302. http://www.dx.doi.org/10.3762/bjoc.8.147
dc.identifier.issn	1860-5397
dc.identifier.uri	http://hdl.handle.net/1808/16108
dc.description	This is the publisher's version, also available electronically from http://www.beilstein-journals.org/bjoc/single/articleFullText.htm?publicId=1860-5397-8-147.
dc.description.abstract	The efficient synthesis of an 80-member library of unique benzoxathiazocine 1,1-dioxides by a microwave-assisted, intermolecular nucleophilic aromatic substitution (SNAr) diversification pathway is reported. Eight benzofused sultam cores were generated by means of a sulfonylation/SNAr/Mitsunobu reaction pairing protocol, and subsequently diversified by intermolecular SNAr with ten chiral, non-racemic amine/amino alcohol building blocks. Computational analyses were employed to explore and evaluate the chemical diversity of the library
dc.publisher	Beilstein-Institut
dc.subject	1-dioxides
dc.subject	benzoxathiazocine 1,1-dioxides
dc.subject	chemical diversity
dc.subject	informatics
dc.subject	nucleophilic aromatic substitution (SNAr)
dc.subject	sultams
dc.title	Exploring chemical diversity via a modular reaction pairing strategy
dc.type	Article
kusw.kuauthor	Loh, Joanna K.
kusw.kuauthor	Yoon, Sun Young
kusw.kuauthor	Samarakoon, Thiwanka Bandara
kusw.kuauthor	Rolfe, Alan
kusw.kuauthor	Porubsky, Patrick R.
kusw.kuauthor	Neuenswander, Benjamin
kusw.kuauthor	Lushington, Gerald H.
kusw.kuauthor	Hanson, Paul R.
kusw.kudepartment	Chemistry
kusw.oastatus	fullparticipation
dc.identifier.doi	10.3762/bjoc.8.147
kusw.oaversion	Scholarly/refereed, publisher version
kusw.oapolicy	This item meets KU Open Access policy criteria.
dc.rights.accessrights	openAccess

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