Exploring chemical diversity via a modular reaction pairing strategy
Issue Date
2012-08-15Author
Loh, Joanna K.
Yoon, Sun Young
Rolfe, Alan
Neuenswander, Benjamin
Lushington, Gerald H.
Hanson, Paul R.
Samarakoon, Thiwanka Bandara
Porubsky, Patrick R.
Publisher
Beilstein-Institut
Type
Article
Article Version
Scholarly/refereed, publisher version
Metadata
Show full item recordAbstract
The efficient synthesis of an 80-member library of unique benzoxathiazocine 1,1-dioxides by a microwave-assisted, intermolecular nucleophilic aromatic substitution (SNAr) diversification pathway is reported. Eight benzofused sultam cores were generated by means of a sulfonylation/SNAr/Mitsunobu reaction pairing protocol, and subsequently diversified by intermolecular SNAr with ten chiral, non-racemic amine/amino alcohol building blocks. Computational analyses were employed to explore and evaluate the chemical diversity of the library
Description
This is the publisher's version, also available electronically from http://www.beilstein-journals.org/bjoc/single/articleFullText.htm?publicId=1860-5397-8-147.
ISSN
1860-5397Collections
Citation
Loh, Joanna K. et al. (2012). "Exploring chemical diversity via a modular reaction pairing strategy." Beilstein Journal of Organic Chemistry, 8:1293-1302. http://www.dx.doi.org/10.3762/bjoc.8.147
Items in KU ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
We want to hear from you! Please share your stories about how Open Access to this item benefits YOU.