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dc.contributor.authorHara, Junichi
dc.contributor.authorBenedict, Stephen H.
dc.contributor.authorMak, Tak W.
dc.contributor.authorGelfand, Erwin W.
dc.date.accessioned2014-11-18T20:45:23Z
dc.date.available2014-11-18T20:45:23Z
dc.date.issued1987-12
dc.identifier.citationHara et al. "T cell receptor alpha-chain gene rearrangements in B-precursor leukemia are in contrast to the findings in T cell acute lymphoblastic leukemia. Comparative study of T cell receptor gene rearrangement in childhood leukemia." J Clin Invest. 1987;80(6):1770–1777. http://dx.doi.org/10.1172/JCI113270.
dc.identifier.urihttp://hdl.handle.net/1808/15793
dc.description.abstractWe have analyzed T cell receptor alpha-chain gene configuration using three genomic joining (J) region probes in 64 children with acute lymphoblastic leukemia (ALL). 11 out of 18 T-ALLs were T3 positive; alpha-chain gene rearrangements were demonstrated in only two of 18, indicating that the majority of T-ALLs would have rearrangements involving J alpha segments located upstream of these probes. In contrast, 15 out of 46 B-precursor ALLs showed rearrangements of the alpha-chain gene and J alpha segments located approximately 20-30 kb upstream of the constant region were involved in 13 of these patients. Nine of 15 B-precursor ALLs with rearranged alpha-chain genes had rearrangements of both gamma- and beta-chain genes, whereas the remaining six had no rearrangements of gamma- and beta-chain genes. These findings indicated that alpha-chain gene rearrangement is not specific for T lineage cells and gamma- and/or beta-chain gene rearrangement does not appear essential for alpha-chain gene rearrangement, at least in B-precursor leukemic cells.
dc.publisherThe American Society for Clinical Investigation
dc.titleT cell receptor alpha-chain gene rearrangements in B-precursor leukemia are in contrast to the findings in T cell acute lymphoblastic leukemia. Comparative study of T cell receptor gene rearrangement in childhood leukemia.
dc.typeArticle
kusw.kuauthorBenedict, Stephen H.
kusw.kudepartmentDepartment of Molecular Biosciences
kusw.oastatusna
dc.identifier.doi10.1172/JCI113270
kusw.oaversionScholarly/refereed, publisher version
kusw.oapolicyThis item does not meet KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


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