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T cell receptor alpha-chain gene rearrangements in B-precursor leukemia are in contrast to the findings in T cell acute lymphoblastic leukemia. Comparative study of T cell receptor gene rearrangement in childhood leukemia.
dc.contributor.author | Hara, Junichi | |
dc.contributor.author | Benedict, Stephen H. | |
dc.contributor.author | Mak, Tak W. | |
dc.contributor.author | Gelfand, Erwin W. | |
dc.date.accessioned | 2014-11-18T20:45:23Z | |
dc.date.available | 2014-11-18T20:45:23Z | |
dc.date.issued | 1987-12 | |
dc.identifier.citation | Hara et al. "T cell receptor alpha-chain gene rearrangements in B-precursor leukemia are in contrast to the findings in T cell acute lymphoblastic leukemia. Comparative study of T cell receptor gene rearrangement in childhood leukemia." J Clin Invest. 1987;80(6):1770–1777. http://dx.doi.org/10.1172/JCI113270. | |
dc.identifier.uri | http://hdl.handle.net/1808/15793 | |
dc.description.abstract | We have analyzed T cell receptor alpha-chain gene configuration using three genomic joining (J) region probes in 64 children with acute lymphoblastic leukemia (ALL). 11 out of 18 T-ALLs were T3 positive; alpha-chain gene rearrangements were demonstrated in only two of 18, indicating that the majority of T-ALLs would have rearrangements involving J alpha segments located upstream of these probes. In contrast, 15 out of 46 B-precursor ALLs showed rearrangements of the alpha-chain gene and J alpha segments located approximately 20-30 kb upstream of the constant region were involved in 13 of these patients. Nine of 15 B-precursor ALLs with rearranged alpha-chain genes had rearrangements of both gamma- and beta-chain genes, whereas the remaining six had no rearrangements of gamma- and beta-chain genes. These findings indicated that alpha-chain gene rearrangement is not specific for T lineage cells and gamma- and/or beta-chain gene rearrangement does not appear essential for alpha-chain gene rearrangement, at least in B-precursor leukemic cells. | |
dc.publisher | The American Society for Clinical Investigation | |
dc.title | T cell receptor alpha-chain gene rearrangements in B-precursor leukemia are in contrast to the findings in T cell acute lymphoblastic leukemia. Comparative study of T cell receptor gene rearrangement in childhood leukemia. | |
dc.type | Article | |
kusw.kuauthor | Benedict, Stephen H. | |
kusw.kudepartment | Department of Molecular Biosciences | |
kusw.oastatus | na | |
dc.identifier.doi | 10.1172/JCI113270 | |
kusw.oaversion | Scholarly/refereed, publisher version | |
kusw.oapolicy | This item does not meet KU Open Access policy criteria. | |
dc.rights.accessrights | openAccess |