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dc.contributor.authorHara, Junichi
dc.contributor.authorBenedict, Stephen H.
dc.contributor.authorYumura, Keiko
dc.contributor.authorHa-Kawa, Kyungsae
dc.contributor.authorGelfand, Erwin W.
dc.date.accessioned2014-11-14T22:40:41Z
dc.date.available2014-11-14T22:40:41Z
dc.date.issued1989-04-01
dc.identifier.citationHara et al. "Rearrangement of Variable Region T Cell Receptor y Genes in Acute Lymphoblastic Leukemia Vy Gene Usage Differs in Mature and Immature T Cells." J Clin Invest. 1989;83(4):1277-1283. http://dx.doi.org/10.1172/JCI114012
dc.identifier.urihttp://hdl.handle.net/1808/15765
dc.description.abstractUsing probes recognizing variable regions (V gamma) and joining regions (J gamma) of the T cell receptor (TCR) gamma gene, we have analyzed the usage of V gamma genes in 24 patients with T cell acute lymphoblastic leukemia (ALL) and 36 patients with B-precursor ALL. In CD3- T-ALL derived from immature T cells, V gamma genes more proximal to J gamma were frequently rearranged; V gamma 8, V gamma 9, V gamma 10, and V gamma 11 were used in 19 of 24 rearrangements. In contrast, CD3+ T-ALL derived from a more mature stage of T cell ontogeny, showed a high frequency of rearrangements involving V gamma genes distal to J gamma; V gamma 2, V gamma 3, V gamma 4, and V gamma 5 were used in 17 of 25 rearrangements. In B-precursor ALL, no notable bias of V gamma gene usage was observed. This probably reflects the possibility that TCR genes may not rearrange according to a T cell hierarchy when under control of a B cell gene program. Furthermore, deletions of those V gamma genes located 3' to rearranged V gamma genes were observed in all patients analyzed. This supports the theory that loop deletion is a major mechanism for TCR-gamma gene rearrangement.
dc.publisherThe American Society for Clinical Investigation
dc.titleRearrangement of Variable Region T Cell Receptor y Genes in Acute Lymphoblastic Leukemia Vy Gene Usage Differs in Mature and Immature T Cells
dc.typeArticle
kusw.kuauthorBenedict, Stephen H.
kusw.kudepartmentDepartment of Molecular Biosciences
kusw.oastatusna
dc.identifier.doi10.1172/JCI114012
kusw.oaversionScholarly/refereed, publisher version
kusw.oapolicyThis item does not meet KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


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