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Chemistry Dissertations and Theses: Recent submissions
Now showing items 81-100 of 335
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I. Polarographic behavior of simple chlorinated organosilanesII. Polarographic investigations in pyridine
(University of Kansas, 1951) -
Studies on nicotinamide
(University of Kansas, 1949) -
Using Fluorescence Derivatization and Analytical Separations to Investigate Biomarkers of Oxidative Stress
(University of Kansas, 2017-08-31)Oxidative stress occurs when there is an overproduction of reactive nitrogen and oxygen species in the body. This condition has been linked to many prominent diseases. This thesis details analytical methods that use ... -
Palladium-Catalyzed Synthesis and Racemization of Conjugated Allenynes
(University of Kansas, 2017-08-31)Allenes are structurally unique compounds that can possess axial chirality. The most common strategy for allene synthesis is transition metal-catalyzed cross coupling with propargyl electrophiles. While these are powerful ... -
Development of Separation-Based Microfluidic Platforms to Study Intracellular Nitrosative and Oxidative Stress
(University of Kansas, 2017-08-31)Nitrosative and oxidative stress are conditions caused by the overproduction of reactive nitrogen and oxygen species (RNOS), respectively. Nitric oxide (NO) and superoxide (O2•−) are the main sources of all RNOS. Macrophages ... -
Probing complex electron dynamics in multieclecton atoms and one electron molecule ion in presence of ultra short laser pulse
(University of Kansas, 2017-08-31)We performed an ab initio and accurate exploration of complex electron dynamics in multieclecton atoms and one electron molecule ion in presence of ultra short laser pulse. Particularly, an ab initio 3D precision calculation ... -
Reorientation Dynamics of Branched and Linear Alcohols
(University of Kansas, 2017-08-31)Molecular reorientation of the four isomeric butanols are investigated with molecular dynamics simulations. The purpose of this study is to probe how alcohol reorientational and hydrogen-bond (H-bond) dynamics is influenced ... -
Synthesis and Characterization of Amide and Urea Receptor Systems for Anion and Metal Complexation and the Synthesis and Use of Block Copolymers for Optoelectronic Crystal Growth
(University of Kansas, 2017-08-31)The content of this dissertation is divided into two parts, as a result of projects from two research groups during the course of my research at the University of Kansas. The first five chapters detail my work with Dr. ... -
High-Throughput Screening (HTS) of Potential Lead Compounds for Target Proteins with No False Identifications Using LC/MS
(University of Kansas, 2017-08-31)Developing effective high throughput screening (HTS) methods is of paramount importance in the early stage of drug discovery. When a protein binding event can be detected via spectroscopy, then absorbance, fluorescence or ... -
Single Molecule Analysis of Biomembrane Heterogeneity
(University of Kansas, 2017-08-31)The biological membrane is a complex and dynamic structure that participates in many important cellular functions. As such, model membranes are frequently employed to study membrane structure and its relationship to function. ... -
On Bilayer Deformation Energetics With and Without Gramicidin A Channel
(University of Kansas, 2017-08-31)Lipid membranes are not simply passive barriers. Embedded proteins are coupled to the membrane and can deform the surrounding bilayer, which incurs an energetic penalty. To minimize these penalties, proteins are known to ... -
A study of some polarization effects in aromatic ethers
(University of Kansas, 1943) -
The determination of ion transference in solutions of electrolytes in anhydrous acetic acid
(University of Kansas, 1938) -
Optimization of Whispering Gallery Mode Microsphere Resonators and Their Application in Biomolecule Sensing
(University of Kansas, 2017-05-31)Optical Whispering gallery mode (WGM) resonators have attracted attention due to their label-free and sensitive detection capabilities for sensing. Light is confined and continuously recirculated within the cavity via total ... -
Electroanalytical measurements of neurotransmitter release and uptake in zebrafish
(University of Kansas, 2016-12-31)Fast-scan cyclic voltammetry at carbon-fiber microelectrodes (FSCV) is a commonly used electrochemical technique to measure sub-second concentration changes in electroactive neurotransmitters, including dopamine, and ... -
The Development of Pot-Economical Strategies for the Synthesis of Natural Products and Analogs
(University of Kansas, 2016-12-31)The development of atom-, redox-, step-, and pot-economical methods for the efficient synthesis of medicinal drugs, bioactive natural products and their synthetic analogs stands at the forefront of modern day organic ... -
ROMP-Derived Alkylating Reagents and Scavengers: Application in Library Development and Sequestration
(University of Kansas, 2016-12-31)The overarching goal of this dissertation is the development and utilization of (ring-opening metathesis polymerization) ROMP-derived high load phosphorus- and sulfur-based soluble, silica and magnetic alkylating reagents ... -
Development and Application of Quinone-Catalyzed C-C Bond Cleavage
(University of Kansas, 2016-08-31)Organocatalysis is a synthetic field of ever increasing development and utility. Of the reactions and small molecule catalysts developed over the last 20 years, a considerable portion have been inspired by cofactors that ... -
P-Stereogenic, Bicyclic Phosphorus Heterocycles and Temporary Tether Strategies for the Synthesis of Complex Polyols
(University of Kansas, 2016-08-31)The development of atom-, redox-, and step-, and pot-economonical strategies for the streamlined synthesis of biologically active small molecules stands at the forefront of modern-day organic synthesis and early-stage drug ... -
Analytical method developments of antibody drug conjugates and disease biomarkers in microdialysis samples
(University of Kansas, 2016-05-31)This dissertation focuses on developing analytical methods to study biomarkers in different pharmaceutical samples. Three different analytical methods were developed for microdialysis samples and antibody drug conjugates ...