ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated.
If you have any questions, please contact Marianne Reed at mreed@ku.edu .
Chemistry Dissertations and Theses: Recent submissions
Now showing items 321-335 of 335
-
The Role of the Leaving Group in the Photo-Favorskii Rearrangement of p-Hydroxyphenacyl
(University of Kansas, 2008-07-28)The p-hydroxyphenacyl group has several features that make it an attractive photoremovable protecting group. Literature examples support this statement and the benzoate, formate, and sulfonate derivatives are not exceptions. ... -
Palladium- and Ruthenium-Catalyzed Decarboxylative Allylations and Michael Addition-Allylation Reactions. Applications in Nitrogen Heterocycle Synthesis
(University of Kansas, 2008-08-21)Our group has a long-standing interest in Pd or Ru-catalyzed decarboxylative coupling reactions. It has been shown that allyl ?-ketoesters, upon treatment with palladium or ruthenium, generate freely diffusing enolates and ... -
Charge Transfer Reactions in Porous Materials
(University of Kansas, 2008-08-15)Porous materials, such as sol-gels and zeolites, contain nanometer-scale spaces in which molecules are confined, leading to significant changes in their chemical dynamics. In this dissertation, the effects of confinement ... -
Structure and Dynamic Studies of the Nuclear Pore Complex at the Single-Molecule Level
(University of Kansas, 2008-08-06)Nuclear pore complexes (NPCs) are large macromolecular structures forming the only known direct route across the double bilayer membrane of the nuclear envelope. The NPC structure has been extensively explored in an effort ... -
A Novel Route to Enantioenriched α-Allyl α-Fluoroketones via Palladium Catalyzed Decarboxylation
(University of Kansas, 2008-08-21)This thesis details the development of a novel catalytic asymmetric route to α-fluorinated ketones. Enantioenriched α-fluoroketones were produced in good yields and high enantiomeric ratios via palladium-catalyzed ... -
Structural and Biochemical Characterization of the Hemophore (HasAp) From Pseudomonas Aeruginosa
(University of Kansas, 2008-07-23)HasAp is a hemophore which is believed to "steal" heme from hemoglobin in the extracellular medium and deliver the heme to the cognate receptor, HasR for internalization. The mechanism of heme uptake and release mechanism ... -
Phosphate Tethers in Synthesis: The Total Synthesis of Dolabelide C.
(University of Kansas, 2008-07-18)The utilization of phosphate tethers in synthesis is the focus of the dissertation research described herein. Specifically, cross metathesis of various olefin partners with a phosphate tether has been demonstrated. These ... -
Studies on interactions of Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA) with anti apoptotic protein Bcl-2.
(University of Kansas, 2008-07-29)Bcl-2 regulates apoptosis by controlling luminal Ca2+ concentration of endoplasmic reticulum (ER). Dremina et al. reported that Bcl-2 interacts with SERCA, the Ca2+ pump in SR/ER membrane, causing inactivation and ... -
Method Development of Characterization of N-linked Glycoproteins in Mass Spectrometry
(University of Kansas, 2008-02-25)Protein glycosylation is one of the most important post-translational modifications, and it is involved in many biological processes, including inter-/intra cell signaling, protein recognition, and receptor binding, etc. ... -
Conformational search of Proteins and Protein Loops
(University of Kansas, 2008-02-26)This thesis focuses on understanding the structure and dynamics of proteins using simulations. The main system of interest in our case was cytochrome b5, an electron transport protein, which exists in both Microsomal and ... -
INVESTIGATIVE PHOTOCHEMISTRY: ELUCIDATING THE MECHANISM OF THE PHOTO-FAVORSKII REARRANGEMENT
(University of Kansas, 2008-04-23)The p-hydroxyphenacyl chromophore (pHP) is a versatile phototrigger for several biological nucleofuges, such as gamma-aminobutyric acid (GABA). The photochemistry is trenchant; irradiation discharges the nucleofuge and ... -
Synthesis and Characterization of Polyamine Bicycles for Anion Binding
(University of Kansas, 2007-10-09)Abstract This thesis details the interaction between anions, such as Br-, Cl-, and F- and a group of familiar Schiff base derived azacryptands. Often these systems are synthesized by tosylating i.e., protecting, the bridging ... -
Development of Analytical Methods Coupled to Microdialysis Sampling for Studying Biomarkers of Oxidative Stress
(University of Kansas, 2007-12-18)This research describes the development of analytical methods based upon separation techniques coupled to microdialysis sampling for the detection of potential biomarkers of oxidative stress. The research focused on two ... -
Synthesis of Sultams and Related Sulfur Heterocycles Using the Ring-Closing Metathesis Reaction
(University of Kansas, 2007-09-19)The use of ring-closing metathesis (RCM) for the construction of small, medium and large rings has become a powerful tool in organic chemistry. The application of this reaction for the construction of sulfur heterocycles ... -
Ligand Design, Coordination and Electrochemistry of Nonbenzenoid Aryl Isocyanides
(University of Kansas, 2007-12-05)Abstract In this work, the strategy for accessing planar chiral isocyanides has been developed and the first member of this family has been isolated in the optically pure form and fully characterized. 2-Methyl-substituted ...