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Chemistry Dissertations and Theses: Recent submissions
Now showing items 241-260 of 335
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Synthetic Approaches to Skeletally Diverse Sultams Using Vinyl- and α-Halo Benzenesulfonamides
(University of Kansas, 2012-08-31)The development of new chemical methods to generate novel and diverse structures to probe chemical space is an important aspect of early phase drug discovery. Diversity-Oriented Synthesis (DOS) is a powerful strategy that ... -
Determination of Lipid Peroxidation Associated with a Focal Seizure Model through In Vivo Microdialysis Sampling
(University of Kansas, 2013-05-31)Two methods were developed to evaluate the extent of lipid peroxidation in an animal model of focal seizures. Microdialysis was used to sample from the extracellular fluid in specific regions of the hippocampus. The first ... -
Conformational Analysis of Disordered Proteins Using H/D Exchange Mass Spectrometry
(University of Kansas, 2013-05-31)Intrinsically disordered proteins (IDPs) represent a growing area of scientific interest. The prevalence of IDPs within the proteomes of complex organisms and the importance of these proteins in cellular functions has ... -
Strain-Release Activation of α,β-Unsaturated Amides Towards Conjugate Addition of N, O and S - Nucleophiles
(University of Kansas, 2013-05-31)This thesis encompasses a novel methodology enabling the diastereoselective addition of heteroatom-centered nucleophiles to the conjugated double bond of in situ-generated α,β - unsaturated cyclopropenyl amides. The ... -
Development of Dual-Electrode Amperometric Detectors for Liquid Chromatography and Capillary Electrophoresis
(University of Kansas, 2013-05-31)Abstract The body of this research was focused on the use and development dual-electrode detection schemes for liquid chromatography and capillary electrophoresis. These detection schemes were developed to investigate redox ... -
STRATEGIC COMBINATION OF TRANSITION METAL-CATALYZED REACTIONS FOR ECONOMICAL ONE-POT SYNTHESES OF N-HETEROCYCLES
(University of Kansas, 2013-08-31)There has been extraordinary progress in the field of chemical synthesis over the last couple of decades. Innovative methodologies and robust catalysts are emerging. Propelled by all these inventions the evolution of the ... -
Development of an Analytical Method for the Detection and Quantitation of Nitrite as a Biomarker of Nitric Oxide and Reactive Nitrogen Species in Biological Samples
(University of Kansas, 2013-05-31)Sean D. Willis, MS Department of Chemistry, December 2012 University of Kansas The brain is a complex organ, consisting of blood vessels, neurons, neuronal support cells, and meninges. The extracellular space surrounding ... -
Carbon Dioxide Fixation in Cultured Animal Cells
(University of Kansas, 1969) -
Reorientation and Solvation Dynamics of Bulk and Confined Alcohols
(University of Kansas, 2012-12-31)Reorientation and solvation dynamics play a central role in chemistry in the liquid phase. In this work, molecular dynamics simulations are used to study hydroxyl group reorientation dynamics for a series of neat linear ... -
Synthetic Entries Into the Bicyclo[2.1.1]Hexane System
(University of Kansas, 1974) -
Intramolecular oxa-Michael and Baylis Hillman Strategies towards Sultam Libraries
(University of Kansas, 2011-05-31)The utilization of Baylis-Hillman and oxa-Michael methodologies for the synthesis of sultam (cyclic sulfonamides) libraries from chiral non-racemic amino alcohols and epoxides is reported. These strategies employ a divergent ... -
Spectroscopic and Computational Studies of the Physical Properties and Reactivities of Peroxomanganese(III) Complexes
(University of Kansas, 2011-05-31)A wide range of MnIII intermediates were generated and studied using various spectroscopic techniques, including electronic absorption, magnetic circular dichroism (MCD), variable-temperature, variable-field (VTVH) MCD, ... -
Development of Methods for the Heteroatom Functionalization of Cyclopropenes
(University of Kansas, 2011-08-31)The main focus of this thesis is the stereoselective funtionalization of cyclopropenes mainly via the addition of H-X (hetroatom-hydrogen) moieties across the strained double bond. It is broken up into three chapters, each ... -
Investigations into Protein-Surface Interactions via Atomic Force Microscopy and Surface Plasmon Resonance
(University of Kansas, 2012-08-31)Protein surface interactions are important in many diverse applications. In this dissertation nonspecific and specific interactions of two proteins (fibrinogen and F1-ATP synthase) with a variety of surfaces have been ... -
Self-Assembly of Azulenic Monolayer Films on Metallic Gold Surfaces
(University of Kansas, 2012-08-31)Derivatives of azulene, an unusual nonbenzenoid aromatic hydrocarbon featuring fused five- and seven-membered sp2 carbon rings, are of substantial current interest in the design of advanced functional materials such as ... -
CHARACTERIZATION OF THE STRUCTURE AND REACTIVITY OF A NICKEL(II)-TRIPEPTIDE MIMIC OF NICKEL SUPEROXIDE DISMUTASE
(University of Kansas, 2012-08-31)The tripeptide asparagine-cysteine-cysteine (NCC) was found by the J. Laurence lab to bind nickel very tightly. In fact, NCC was serendipitously discovered as a metal-abstraction peptide tag (MAP-tag) because it was stripping ... -
Qualitative and quantitative analysis of proteolytically digested glycoproteins by mass spectrometry
(University of Kansas, 2011-05-31)Glycoproteins are a very large and biologically relevant class of proteins that comprise more than 50 % of proteins in the human body. The glycosylation present on proteins, specifically N-linked glycosylation has been ... -
Structure/Function Relationships in Nickel-Peptide Complexes: Impact of the Primary Coordination Sphere on Square-Planar Nickel Chemistry
(University of Kansas, 2011-05-31)The novel metal-binding tripeptide asparagine-cysteine-cysteine (NCC) is capable of coordinating a metal ion, and we are exploring its use in several biological applications. Different metals may be incorporated into this ... -
Dopamine Release and Uptake in Animal Models of Neurological Diseases
(University of Kansas, 2011-5-31)Fast scan cyclic voltammetry (FSCV) can be utilized to detect neurotransmitter release and uptake in brain slices. When combining this technique with disease state animals models, information for therapeutic targets can ...