ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated.
If you have any questions, please contact Marianne Reed at mreed@ku.edu .
A novel bocavirus in canine liver
dc.contributor.author | Li, Linlin | |
dc.contributor.author | Pesavento, Patricia A. | |
dc.contributor.author | Leutenegger, Christian M. | |
dc.contributor.author | Estrada, Marko | |
dc.contributor.author | Coffey, Lark L. | |
dc.contributor.author | Naccache, Samia N. | |
dc.contributor.author | Samayoa, Erik | |
dc.contributor.author | Chiu, Charles | |
dc.contributor.author | Qiu, Jianming | |
dc.contributor.author | Wang, Chunlin | |
dc.contributor.author | Deng, Xutao | |
dc.contributor.author | Delwart, Eric | |
dc.date.accessioned | 2014-01-17T20:18:44Z | |
dc.date.available | 2014-01-17T20:18:44Z | |
dc.date.issued | 2013-02-13 | |
dc.identifier.citation | Li, Linlin, Patricia A Pesavento, Christian M Leutenegger, Marko Estrada, Lark L Coffey, Samia N Naccache, Erik Samayoa, et al. 2013. “A Novel Bocavirus in Canine Liver.” Virology Journal 10:54. http://dx.doi.org/10.1186/1743-422X-10-54. | |
dc.identifier.uri | http://hdl.handle.net/1808/12812 | |
dc.description.abstract | Background: Bocaviruses are classified as a genus within the Parvoviridae family of single-stranded DNA viruses and are pathogenic in some mammalian species. Two species have been previously reported in dogs, minute virus of canines (MVC), associated with neonatal diseases and fertility disorders; and Canine bocavirus (CBoV), associated with respiratory disease. Findings: In this study using deep sequencing of enriched viral particles from the liver of a dog with severe hemorrhagic gastroenteritis, necrotizing vasculitis, granulomatous lymphadenitis and anuric renal failure, we identified and characterized a novel bocavirus we named Canine bocavirus 3 (CnBoV3). The three major ORFs of CnBoV3 (NS1, NP1 and VP1) shared less than 60% aa identity with those of other bocaviruses qualifying it as a novel species based on ICTV criteria. Inverse PCR showed the presence of concatemerized or circular forms of the genome in liver. Conclusions: We genetically characterized a bocavirus in a dog liver that is highly distinct from prior canine bocaviruses found in respiratory and fecal samples. Its role in this animal’s complex disease remains to be determined. Keywords: Canine bocavirus 3; Episome; Coinfection | |
dc.publisher | BioMed Central | |
dc.rights | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |
dc.rights.uri | http://creativecommons.org/licenses/by/2.0 | |
dc.subject | Canine-bocavirus-3 | |
dc.subject | Episome | |
dc.subject | Coinfection | |
dc.title | A novel bocavirus in canine liver | |
dc.type | Article | |
kusw.kuauthor | Qiu, Jianming | |
kusw.kudepartment | Microbiology, Molecular Genetics and Immunology | |
kusw.oastatus | fullparticipation | |
dc.identifier.doi | 10.1186/1743-422X-10-54 | |
kusw.oaversion | Scholarly/refereed, publisher version | |
kusw.oapolicy | This item meets KU Open Access policy criteria. | |
dc.rights.accessrights | openAccess |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's license is described as: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.