A novel bocavirus in canine liver
dc.contributor.author | Li, Linlin | |
dc.contributor.author | Pesavento, Patricia A. | |
dc.contributor.author | Leutenegger, Christian M. | |
dc.contributor.author | Estrada, Marko | |
dc.contributor.author | Coffey, Lark L. | |
dc.contributor.author | Naccache, Samia N. | |
dc.contributor.author | Samayoa, Erik | |
dc.contributor.author | Chiu, Charles | |
dc.contributor.author | Qiu, Jianming | |
dc.contributor.author | Wang, Chunlin | |
dc.contributor.author | Deng, Xutao | |
dc.contributor.author | Delwart, Eric | |
dc.date.accessioned | 2014-01-17T20:18:44Z | |
dc.date.available | 2014-01-17T20:18:44Z | |
dc.date.issued | 2013-02-13 | |
dc.identifier.citation | Li, Linlin, Patricia A Pesavento, Christian M Leutenegger, Marko Estrada, Lark L Coffey, Samia N Naccache, Erik Samayoa, et al. 2013. “A Novel Bocavirus in Canine Liver.” Virology Journal 10:54. http://dx.doi.org/10.1186/1743-422X-10-54. | |
dc.identifier.uri | http://hdl.handle.net/1808/12812 | |
dc.description.abstract | Background: Bocaviruses are classified as a genus within the Parvoviridae family of single-stranded DNA viruses and are pathogenic in some mammalian species. Two species have been previously reported in dogs, minute virus of canines (MVC), associated with neonatal diseases and fertility disorders; and Canine bocavirus (CBoV), associated with respiratory disease. Findings: In this study using deep sequencing of enriched viral particles from the liver of a dog with severe hemorrhagic gastroenteritis, necrotizing vasculitis, granulomatous lymphadenitis and anuric renal failure, we identified and characterized a novel bocavirus we named Canine bocavirus 3 (CnBoV3). The three major ORFs of CnBoV3 (NS1, NP1 and VP1) shared less than 60% aa identity with those of other bocaviruses qualifying it as a novel species based on ICTV criteria. Inverse PCR showed the presence of concatemerized or circular forms of the genome in liver. Conclusions: We genetically characterized a bocavirus in a dog liver that is highly distinct from prior canine bocaviruses found in respiratory and fecal samples. Its role in this animal’s complex disease remains to be determined. Keywords: Canine bocavirus 3; Episome; Coinfection | |
dc.publisher | BioMed Central | |
dc.rights | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |
dc.rights.uri | http://creativecommons.org/licenses/by/2.0 | |
dc.subject | Canine-bocavirus-3 | |
dc.subject | Episome | |
dc.subject | Coinfection | |
dc.title | A novel bocavirus in canine liver | |
dc.type | Article | |
kusw.kuauthor | Qiu, Jianming | |
kusw.kudepartment | Microbiology, Molecular Genetics and Immunology | |
kusw.oastatus | fullparticipation | |
dc.identifier.doi | 10.1186/1743-422X-10-54 | |
kusw.oaversion | Scholarly/refereed, publisher version | |
kusw.oapolicy | This item meets KU Open Access policy criteria. | |
dc.rights.accessrights | openAccess |
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Except where otherwise noted, this item's license is described as: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.