Objective: The primary purpose of this study was to examine the construct validity of a continuous metabolic syndrome score (cMetS) in children. The secondary purpose was to identify a cutpoint value(s) for an adverse
cMetS based on receiver operating characteristic (ROC) curve analysis.
Methods: 378 children aged 7 to 9 years were assessed for the metabolic syndrome which was determined by
age-modified cutpoints. High-density-lipoprotein cholesterol, triglycerides, the homeostasis assessment model of insulin resistance, mean arterial pressure, and waist circumference were used to create a cMetS for each subject.
Results: About half of the subjects did not possess any risk factors while about 5% possessed the metabolic
syndrome. There was a graded relationship between the cMetS and the number of adverse risk factors. The cMetS
was lowest in the group with no adverse risk factors (-1.59 ± 1.76) and highest in those possessing the metabolic syndrome (≥3 risk factors) (7.05 ± 2.73). The cutoff level yielding the maximal sensitivity and specificity for predicting the presence of the metabolic syndrome was a cMetS of 3.72 (sensitivity = 100%, specificity = 93.9%,
and the area of the curve = 0.978 (0.957-0.990, 95% confidence intervals).
Conclusion: The results demonstrate the construct validity for the cMetS in children. Since there are several drawbacks to identifying a single cut-point value for the cMetS based on this sample, we urge researchers to use the approach herein to validate and create a cMetS that is specific to their study population.
Eisenmann, Joey C, Kelly R Laurson, Katrina D DuBose, Bryan K Smith, and Joseph E Donnelly. 2010. “Construct Validity of a Continuous Metabolic Syndrome Score in Children.” Diabetology & Metabolic Syndrome 2:8. http://dx.doi.org/10.1186/1758-5996-2-8.