dc.contributor.author | Lundquist, Erik A. | |
dc.contributor.author | Reddien, Peter W. | |
dc.contributor.author | Hartwieg, Erika | |
dc.contributor.author | Horvitz, H. Robert | |
dc.contributor.author | Bargmann, Cornelia I. | |
dc.date.accessioned | 2007-04-04T19:14:35Z | |
dc.date.available | 2007-04-04T19:14:35Z | |
dc.date.issued | 2001-11 | |
dc.identifier.citation | Lundquist, EA; Reddien, PW; Hartwieg, E; Horvitz, HR; Bargmann, CI. Three C-elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis. DEVELOPMENT. NOV 2001. 122(22): 4475-4488. | |
dc.identifier.other | http://dev.biologists.org/ | |
dc.identifier.uri | http://hdl.handle.net/1808/1264 | |
dc.description.abstract | The Caenorhabditis elegans genome contains three rac-like genes, ced-10, mig-2, and rac-2. We report that ced-10, mig-2 and rac-2 act redundantly in axon pathfinding: inactivating one gene had little effect, but inactivating two or more genes perturbed both axon outgrowth and guidance. mig-2 and ced-10 also have redundant functions in some cell migrations. By contrast, ced-10 is uniquely required for cell-corpse phagocytosis, and mig-2 and rac-2 have only subtle roles in this process. Rac activators are also used differentially. The UNC-73 Trio Rac GTP exchange factor affected all Rac pathways in axon pathfinding and cell migration but did not affect cell-corpse phagocytosis. CED-5 DOCK180, which acts with CED-10 Rac in cell-corpse phagocytosis, acted with MIG-2 but not CED-10 in axon pathfinding. Thus, distinct regulatory proteins modulate Rac activation and function in different developmental processes. | |
dc.language.iso | en_US | |
dc.publisher | COMPANY OF BIOLOGISTS LTD | |
dc.subject | C. elegans | |
dc.subject | Rac | |
dc.subject | ced-10 | |
dc.subject | mig-2 | |
dc.subject | Rac-2 | |
dc.subject | Axon pathfinding | |
dc.subject | migration | |
dc.subject | Phagocytosis | |
dc.title | Three C-elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis | |
dc.type | Article | |
dc.rights.accessrights | openAccess | |