ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated.
If you have any questions, please contact Marianne Reed at mreed@ku.edu .
Three C-elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis
dc.contributor.author | Lundquist, Erik A. | |
dc.contributor.author | Reddien, Peter W. | |
dc.contributor.author | Hartwieg, Erika | |
dc.contributor.author | Horvitz, H. Robert | |
dc.contributor.author | Bargmann, Cornelia I. | |
dc.date.accessioned | 2007-04-04T19:14:35Z | |
dc.date.available | 2007-04-04T19:14:35Z | |
dc.date.issued | 2001-11 | |
dc.identifier.citation | Lundquist, EA; Reddien, PW; Hartwieg, E; Horvitz, HR; Bargmann, CI. Three C-elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis. DEVELOPMENT. NOV 2001. 122(22): 4475-4488. | |
dc.identifier.other | http://dev.biologists.org/ | |
dc.identifier.uri | http://hdl.handle.net/1808/1264 | |
dc.description.abstract | The Caenorhabditis elegans genome contains three rac-like genes, ced-10, mig-2, and rac-2. We report that ced-10, mig-2 and rac-2 act redundantly in axon pathfinding: inactivating one gene had little effect, but inactivating two or more genes perturbed both axon outgrowth and guidance. mig-2 and ced-10 also have redundant functions in some cell migrations. By contrast, ced-10 is uniquely required for cell-corpse phagocytosis, and mig-2 and rac-2 have only subtle roles in this process. Rac activators are also used differentially. The UNC-73 Trio Rac GTP exchange factor affected all Rac pathways in axon pathfinding and cell migration but did not affect cell-corpse phagocytosis. CED-5 DOCK180, which acts with CED-10 Rac in cell-corpse phagocytosis, acted with MIG-2 but not CED-10 in axon pathfinding. Thus, distinct regulatory proteins modulate Rac activation and function in different developmental processes. | |
dc.language.iso | en_US | |
dc.publisher | COMPANY OF BIOLOGISTS LTD | |
dc.subject | C. elegans | |
dc.subject | Rac | |
dc.subject | ced-10 | |
dc.subject | mig-2 | |
dc.subject | Rac-2 | |
dc.subject | Axon pathfinding | |
dc.subject | migration | |
dc.subject | Phagocytosis | |
dc.title | Three C-elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis | |
dc.type | Article | |
dc.rights.accessrights | openAccess |