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Dissertations and Theses: Recent submissions
Now showing items 1401-1420 of 9900
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The functional role and regulation of interferon induced transmembrane protein-1 in triple negative breast cancer
(University of Kansas, 2021-05-31)Breast cancer is the most common cancer diagnosed among women in the United States. Breast cancer is subdivided into groups based on receptor status including estrogen receptor (ER) and progesterone receptor (PR) positive, ... -
The feasibility and trend of functional changes by using home-based exercise program delivered through telehealth platform for adolescents with spastic cerebral palsy: The impact of tele-coaching
(University of Kansas, 2021-05-31)The most common type of cerebral palsy (CP) is spastic CP, representing around 82% of all CP types. Individuals with spastic CP usually receive intensive physical therapy during childhood years to improve gross motor ... -
Investigating Human-Animal Interactions in Homes of Children with Autism Spectrum Disorders: A Mixed Methods Approach
(University of Kansas, 2021-05-31)Through my doctoral program, I have developed a growing interest in looking at everyday experiences between people and animals, and how to examine human-animal relationships. My interest has transitioned to home-based ... -
Probing contributions of Apolipoprotein E4 to cerebrovascular dysfunction and Alzheimer's disease
(University of Kansas, 2021-05-31)Evidence increasingly points to an early and primary role for vascular dysfunction in the pathogenesis of late-onset Alzheimer’s disease (AD). This early vascular dysfunction may be particularly impactful for people at the ... -
Faculty Perceptions of Nursing Student Retention in Community College Associate Degree Programs: A Qualitative Descriptive Study
(University of Kansas, 2021-05-31)Understanding the factors that influence nursing students to stay or leave a nursing program is vital to ensure our population has prepared nurses to care. Low student retention leads to fewer nurse graduates, negatively ... -
Deconstructing Unconscious Bias in the Health Care Workforce: An Iterative Mixed Methods Approach
(University of Kansas, 2021-05-31)The prevalence of unconscious bias within the healthcare workforce is not well understood. Likewise, not much is known about the potential impacts of unconscious bias training interventions on the healthcare workforce as ... -
Weighing In: Overweight, Working Women’s Descriptions of Body Weight and Weight Management
(University of Kansas, 2021-05-31)Obesity is a growing public health concern associated with poor health outcomes, increased healthcare costs, and decreased human productivity. Women are inordinately impacted by obesity. The insidious nature of weight gain ... -
Metering Mood with Veggies: Association of skin carotenoid levels and depressive symptoms or mood disturbances
(University of Kansas, 2021-05-31)Background: Mood disturbances and depressive symptoms are a common occurrence among those with Alzheimer’s disease (AD). They are associated with poor quality of life for the person with AD, as well as increased caregiver ... -
From Candy to Chemotherapy: Characterizing Sensory Neuropathy Associated with Prediabetes and Paclitaxel Treatment
(University of Kansas, 2021-05-31)Peripheral neuropathy is one of the major co-morbidities associated with diabetes mellitus. Neurotoxic chemotherapies including paclitaxel also display significant risk of development of peripheral neuropathy. It is ... -
Staphylococcus aureus and Fatty Acids: Impact on Membrane Function and Signaling
(University of Kansas, 2021-05-31)Staphylococcus aureus can utilize exogenous fatty acids for phospholipid synthesis. The fatty acid kinase FakA is essential for this utilization by phosphorylating exogenous fatty acids for incorporation into lipids. How ... -
Tumor infiltrating lymphocyte therapy for renal cell carcinoma: methods for ex vivo expansion and T-cell memory induction
(University of Kansas, 2020-06-31)Tumor infiltrating lymphocyte (TIL) therapy is a personalized treatment for locally advanced or metastatic cancer. TIL therapy requires the surgical excision of a portion of the malignant tissue and subsequent ex vivo ... -
The Association of Hyperglycemia with Airway Epithelial Cell Ion Channel Dysfunction in Cystic Fibrosis
(University of Kansas, 2021-01-01)Cystic fibrosis-related diabetes (CFRD) is a common extrapulmonary comorbidity in adults with CF and portends worse outcomes. However, a direct link between hyperglycemia and decline in lung function is unknown. Inflammation ... -
The association of dietary protein and vitamin D with body composition and exercise outcomes in cognitively normal older adults
(University of Kansas, 2021-05-31)Background: Aging is associated with many degenerative diseases such as osteoporosis and sarcopenia due to bone and muscle loss. Sarcopenia is a prevalent geriatric syndrome, characterized by decreased skeletal muscle mass, ... -
Pediatric Obesity Consequences and Interventions: Characteristics Associated with Successful Weight Management in Children and Adolescents with Obesity
(University of Kansas, 2021-05-31)Over the past three decades, pediatric obesity rates have tripled in the United States and affected 18.5% of children and adolescents. Obesity can affect all aspects of children and adolescents' life including their physical ... -
Nascent Wars: How RARE enhancers regulate Hoxb gene transcripts
(University of Kansas, 2021-05-21)During development of an embryo, the anterior-posterior (A-P) body axis has to be properly defined, in order for body segments and organs to form in their correct locations. A family of transcription factors, the Hox genes, ... -
CCL2/CCR2 chemokine signaling modulates ductal breast cancer progression by enhancing glycolysis and c-MET activation
(University of Kansas, 2021-05-31)Despite therapeutic advancement, ductal carcinoma in situ (DCIS) remains the most common form of pre- invasive breast cancer diagnosed among women with 60,000 cases every year. Treatment for DCIS involves a combination of ... -
Uncovering Mechanisms Behind Simple Steatosis Progression to Non-Alcoholic Steatohepatitis
(University of Kansas, 2020-08-31)Non-alcoholic fatty liver disease (NAFLD) is the most common type of chronic liver disease in the Western countries. NAFLD encompasses the entire spectrum of fatty liver disease in individuals without significant alcohol ... -
Prediabetes: Clinical Management and Nutrient Patterns Related to Diabetes Development
(University of Kansas, 2020-08-31)Background: Greater than one third of US adults have prediabetes, rising to nearly half of adults over the age of 65. Increased cardiometabolic health risks exist already in prediabetes and incur costs greater than $40 ... -
Maintaining genomic stability: from DNA polymerase β to telomerase
(University of Kansas, 2020-08-31)One vital aspect of genomic stability is the maintenance of repetitive DNA sequences at the end of eukaryotic chromosomes known as telomeres. Telomere DNA shortens with every eukaryotic cell division, increasing the ... -
The effect of oxidized guanines on DNA synthesis by DNA polymerase β
(University of Kansas, 2020-08-31)DNA replication is the fundamental biological task of duplicating genetic information for passing on to a daughter cell. DNA polymerases are the molecular machines that read the parent DNA strand and instruct the addition ...