Chemistry Scholarly Works: Recent submissions
Now showing items 601-620 of 629
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Single molecule quantitation and sequencing of rare translocations using microfluidic nested digital PCR
(Oxford University Press, 2013-06-23)Cancers are heterogeneous and genetically unstable. New methods are needed that provide the sensitivity and specificity to query single cells at the genetic loci that drive cancer progression, thereby enabling researchers ... -
Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assays
(Oxford University Press, 2012-06-27)Typical assays used to discover and analyze small molecules that inhibit the hepatitis C virus (HCV) NS3 helicase yield few hits and are often confounded by compound interference. Oligonucleotide binding assays are examined ... -
P20-08. Glycosylation: an important factor in Env diversity
(BioMed Central, 2009-10-22) -
Function Annotation of Hepatic Retinoid x Receptor α Based on Genome-Wide DNA Binding and Transcriptome Profiling
(Public LIbrary of Science, 2012-11-15)Background Retinoid x receptor α (RXRα) is abundantly expressed in the liver and is essential for the function of other nuclear receptors. Using chromatin immunoprecipitation sequencing and mRNA profiling data generated ... -
Envelope Deglycosylation Enhances Antigenicity of HIV-1 gp41 Epitopes for Both Broad Neutralizing Antibodies and Their Unmutated Ancestor Antibodies
(Public Library of Science, 2011-09-01)The HIV-1 gp41 envelope (Env) membrane proximal external region (MPER) is an important vaccine target that in rare subjects can elicit neutralizing antibodies. One mechanism proposed for rarity of MPER neutralizing antibody ... -
Stabilizing Exposure of Conserved Epitopes by Structure Guided Insertion of Disulfide Bond in HIV-1 Envelope Glycoprotein
(Public Library of Science, 2013-10-13)Entry of HIV-1 into target cells requires binding of the viral envelope glycoprotein (Env) to cellular receptors and subsequent conformational changes that culminates in fusion of viral and target cell membranes. Recent ... -
Automated Builder and Database of Protein/Membrane Complexes for Molecular Dynamics Simulations
(Public Library of Science, 2007-09-12)Molecular dynamics simulations of membrane proteins have provided deeper insights into their functions and interactions with surrounding environments at the atomic level. However, compared to solvation of globular proteins, ... -
Symmetry-Defying Iron Pyrite (FeS2) Nanocrystals through Oriented Attachment
(Nature Publishing Group, 2013-06-28)Iron pyrite (fool's gold, FeS2) is a promising earth abundant and environmentally benign semiconductor material that shows promise as a strong and broad absorber for photovoltaics and high energy density cathode material ... -
Programmable active droplet generation enabled by integrated pneumatic micropumps
(RSC Publishing, 2013)In this work we have investigated the integrated diaphragm micropump as an active fluidic control approach for the on-demand generation of droplets with precisely defined size, frequency and timing. In contrast to ... -
Anodic Oxidation of m-terphenyl thio-, seleno-and telluroethers: Lowered oxidation potentials due to chalcogen.•••π interaction
(International Union of Pure and Applied Chemistry, 2010-02)The electrochemistry of m-terphenylthio-, seleno-, and telluroethers was studied using cyclic voltammetry in acetonitrile. All of the compounds studied showed irreversible oxidations. The first oxidation potentials for the ... -
Spectroelectrochemistry: A Survey of In-Situ Spectroscopic Techniques
(International Union of Pure and Applied Chemistry, 1998)In this technical paper a summary of the available in situ spectroelectrochemical methods, their basic principles, their typical applications, and their limitations is given. With respect to the names of the methods and ... -
Orientational Dynamics and Dye-DNA Interactions in a Dye-Labeled DNA Aptamer
(Biophysical Society, 2005-05)We report the picosecond and nanosecond timescale rotational dynamics of a dye-labeled DNA oligonucleotide or ‘‘aptamer’’ designed to bind specifically to immunoglobulin E. Rotational dynamics in combination with fluorescence ... -
Electrochemical Biosensors: Recommended Definitions and Classification
(International Union of Pure and Applied Chemistry, 1999)Two Divisions of the International Union of Pure and Applied Chemistry (IUPAC), namely Physical Chemistry (Commission I.7 on Biophysical Chemistry, formerly Steering Committee on Biophysical Chemistry) and Analytical ... -
Measurement of pH. Definition, Standards, and Procedures
(International Union of Pure and Applied Chemistry, 2002)The definition of a “primary method of measurement” [1] has permitted a full consideration of the definition of primary standards for pH, determined by a primary method (cell without transference, Harned cell), of the ... -
Encrypted testimony of Ben Jonson and his contemporaries for who “William Shakespeare” really was
(Shanxi Agricultural University, Taigu, Shanxi, China, 2009-11)Concealed messages in three authentic Early Modern English sources reveal that Ben Jonson and his contemporaries recognized “William Shakespeare” was a pen name of Edward de Vere, 17th Earl of Oxford (1550–1604). This view ... -
An automated tracer dispersal system for snow accumulation and saltation transport investigations
(AMER INST PHYSICS, 1998-02)New automated instrumentation to assess detailed spatial and temporal dynamics of snow accumulation and saltation transport of snow in remote, harsh environments is described. The instrumentation and techniques provide ... -
Effects of pulse shape on rf SQUID quantum gates
(IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC, 2003-06)Effects of control-signal microwave pulse shapes on rf SQUID quantum gates are investigated. It is shown that the gate operations are mainly affected by microwave pulse area and are independent of pulse shape in the weak ... -
Quantum entanglement and controlled logical gates using coupled SQUID flux qubits
(IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC, 2005-06)We present an approach to realize universal two-bit quantum gates using two SQUID flux qubits. In this approach the basic unit consists of two inductively coupled SQUIDs with realistic device parameters. Quantum logical ... -
Rapid optimization of working parameters of microwave-driven multilevel qubits for minimal gate leakage
(AMERICAN PHYSICAL SOC, 2005-09-16)We propose an effective method to optimize the working parameters (WPs) of microwave-driven quantum gates implemented with multilevel qubits. We show that by treating transitions between each pair of levels independently, ... -
Laser-beam spatial profile analysis using a two-dimensional photo-diode array
(AMER INST PHYSICS, 1983)