ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated.
If you have any questions, please contact Marianne Reed at mreed@ku.edu .
Mammographic density does not correlate with Ki-67 expression or cytomorphology in benign breast cells obtained by random periareolar fine needle aspiration from women at high risk for breast cancer
dc.contributor.author | Qamar Khan | en_US |
dc.contributor.author | Bruce Kimler | en_US |
dc.contributor.author | Anne O'Dea | en_US |
dc.contributor.author | Carola Zalles | en_US |
dc.contributor.author | Priyanka Sharma | en_US |
dc.contributor.author | Carol Fabian | en_US |
dc.date.accessioned | 2009-05-05T16:16:46Z | |
dc.date.available | 2009-05-05T16:16:46Z | |
dc.date.issued | 2008-11-05 | en_US |
dc.identifier.citation | Qamar Khan;Bruce Kimler;Anne O'Dea;Carola Zalles;Priyanka Sharma;Carol Fabian: Mammographic density does not correlate with Ki-67 expression or cytomorphology in benign breast cells obtained by random periareolar fine needle aspiration from women at high risk for breast cancer. Breast Cancer Research 2007, 9(3):R35. | en_US |
dc.identifier.uri | http://hdl.handle.net/2271/627 | en_US |
dc.description.abstract | BACKGROUND:Ki-67 expression is a possible risk biomarker and is currently being used as a response biomarker in chemoprevention trials. Mammographic breast density is a risk biomarker and is also being used as a response biomarker. We previously showed that Ki-67 expression is higher in specimens of benign breast cells exhibiting cytologic atypia that are obtained by random periareolar fine needle aspiration (RPFNA). It is not known whether there is a correlation between mammographic density and Ki-67 expression in benign breast ductal cells obtained by RPFNA.METHODS:Included in the study were 344 women at high risk for developing breast cancer (based on personal or family history), seen at The University of Kansas Medical Center high-risk breast clinic, who underwent RPFNA with cytomorphology and Ki-67 assessment plus a mammogram. Mammographic breast density was assessed using the Cumulus program. Categorical variables were analyzed by ?2 test, and continuous variables were analyzed by nonparametric test and linear regression.RESULTS:Forty-seven per cent of women were premenopausal and 53% were postmenopausal. The median age was 48 years, median 5-year Gail Risk was 2.2%, and median Ki-67 was 1.9%. The median mammographic breast density was 37%. Ki-67 expression increased with cytologic abnormality (atypia versus no atypia; P = 0.001) and younger age (=50 years versus >50 years; P = 0.001). Mammographic density was higher in premenopausal women (P = 0.001), those with lower body mass index (P < 0.001), and those with lower 5-year Gail risk (P = 0.001). Mammographic density exhibited no correlation with Ki-67 expression or cytomorphology.CONCLUSION:Given the lack of correlation of mammographic breast density with either cytomorphology or Ki-67 expression in RPFNA specimens, mammographic density and Ki-67 expression should be considered as potentially complementary response biomarkers in breast cancer chemoprevention trials. | en_US |
dc.language | en | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | BioMedCentral | en_US |
dc.relation.isversionof | http://breast-cancer-research.com/content/9/3/R35 | en_US |
dc.relation.hasversion | http://www.biomedcentral.com/content/pdf/bcr1683.pdf | en_US |
dc.rights | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by/2.0 | en_US |
dc.title | Mammographic density does not correlate with Ki-67 expression or cytomorphology in benign breast cells obtained by random periareolar fine needle aspiration from women at high risk for breast cancer | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1186/bcr1683 | en_US |
dc.identifier.pmid | PMC19351424 | en_US |
dc.rights.accessrights | openAccess | en_US |
dc.date.captured | 2009-04-27 | en_US |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's license is described as: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.