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Chemistry: Recent submissions
Now showing items 241-260 of 964
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Glycoprotein and glycopeptide analysis by liquid chromatography and mass spectrometry
(University of Kansas, 2015-08-31)Carbohydrates on proteins play essential roles in mediating various biological activities, such as cell adhesion, cell signaling, and antigen-antibody recognition. Altered glycosylation profiles on proteins have been found ... -
Formation, Characterization, and Oxidative Reactivity of Bio-inspired Peroxo- and Hydroxo-manganese(III) Complexes
(University of Kansas, 2015-08-31)Manganese-dependent enzymes that react with dioxygen and its reduced derivatives are ubiquitous in nature, catalyzing pivotal processes such as the light-driven oxidation of water to dioxygen, generation of peroxidized ... -
Phosphate Tether-Mediated Metathesis Studies and Application Towards Natural Product Synthesis
(University of Kansas, 2015-08-31)Over the past decade, work in our lab has focused on phosphate tether-mediated desymmetrization of C2-symmetric 1,3-anti-dienediol via ring-closing metathesis (RCM) to afford P-stereogenic bicyclo[4.3.1]phosphates. However, ... -
Modular Approaches to Skeletally Diverse and Stereochemically-rich 7- to 11-membered Ring Sultams
(University of Kansas, 2015-08-31)The overarching goal of this dissertation is the development of efficient methods for the generation of medium- and large-sized heterocycles, specifically 7- to 11-membered sultams, for facilitating probe and drug discovery. ... -
Neurochemical Measurements in Animal Models of Neurodegeneration and Neurotoxicity
(University of Kansas, 2015-08-31)This dissertation is a compilation of work in which selected analytical methods, including fast-scan cyclic voltammetry at carbon-fiber microelectrodes (FSCV), were used to determine neurotransmitter release and uptake ... -
Synthesis of Novel Sultam Scaffolds: Method and Library Development
(University of Kansas, 2015-08-31)The development of methods to produce diverse set of small molecules to be utilized as chemical probes in chemical biology is a continuing emerging area critical in the pursuit of broadening the understanding of biological ... -
Disulfide Analysis with Mass Spectrometry: Toward Biotherapeutic Characterization
(University of Kansas, 2015-08-31)Proteins continue to increase in use as biotherapeutic agents but need to be analyzed to verify efficacy and safety. For instance, disulfide bonds are a protein posttranslational modification (PTM) that are critically ... -
The Role of Iron Storage Proteins in Pseudomonas aeruginosa Bacterial Iron Homeostasis
(University of Kansas, 2016-08-31)Pseudomonas aeruginosa is a gram-negative bacterium that causes infections in immune compromised patients. There have been an increasing number of multi-drug resistant P. aeruginosa infections which is leading to the need ... -
Characterizing Residue-Bilayer Interactions Using Gramicidin A as a Scaffold and Tryptophan Substitutions as Probes
(American Chemical Society, 2017-10-10)Previous experiments have shown that the lifetime of a gramicidin A dimer channel (which forms from two non-conducting monomers) in a lipid bilayer is modulated by mutations of the tryptophan (Trp) residues at the bilayer-water ... -
Excitation by Axon Terminal GABA Spillover in a Sound Localization Circuit
(Society for Neuroscience, 2016-01-20)Synapses from neurons of the medial nucleus of the trapezoid body (MNTB) onto neurons of the lateral superior olive (LSO) in the auditory brainstem are glycinergic in maturity, but also GABAergic and glutamatergic in ... -
Generation and Characterization of a Bivalent HIV-1 Subtype C gp120 Protein Boost for Proof-of-Concept HIV Vaccine Efficacy Trials in Southern Africa
(Public Library of Science, 2016-07-21)The viral envelope glycoprotein (Env) is the major target for antibody (Ab)-mediated vaccine development against the Human Immunodeficiency Virus type 1 (HIV-1). Although several recombinant Env antigens have been evaluated ... -
Point charge embedding for ONIOM excited states calculations
(AIP Publishing, 2016-12-15)Hybrid quantum mechanical methods can assist in the interpretation and prediction of the electronic spectra of large molecular structures. In this work, we study the performance of the ONIOM (Our own N-layered Integrated ... -
Multi-state extrapolation of UV/Vis absorption spectra with QM/QM hybrid methods
(AIP Publishing, 2016-05)In this work, we present a simple approach to simulate absorption spectra from hybrid QM/QM calculations. The goal is to obtain reliable spectra for compounds that are too large to be treated efficiently at a high level ... -
Proton – hydride tautomerism in hydrogen evolution catalysis
(American Society for Biochemistry and Molecular Biology, 2016-04-17)Efficient generation of hydrogen from renewable resources requires development of catalysts that avoid deep wells and high barriers. Information about the energy landscape for H2 production can be obtained by chemical ... -
Nonlinear Excitation of Photoactivated Molecules: Two-Photon Absorption Spectroscopy, Dynamics, and Quantum Yields
(University of Kansas, 2015-12-31)Higher-lying excited electronic states of model, photoactivated molecules are studied using nonlinear excitation to explore the electronic spectroscopy, excited-state dynamics, and reaction quantum yields. The photoactivated ... -
A study of the solubility of nitrates in anhydrous acetic acid
(University of Kansas, 1932) -
A study of the silicon boron phases and a determination of the enthalpy of vaporization and formation of silicon hexaboride
(University of Kansas, 1960) -
Lanthanide boride systems and properties
(University of Kansas, 1964) -
Improving the immunogenicity of native-like HIV-1 envelope trimers by hyperstabilization
(Elsevier, 2017-08-22)The production of native-like recombinant versions of the HIV-1 envelope glycoprotein (Env) trimer requires overcoming the natural flexibility and instability of the complex. The engineered BG505 SOSIP.664 trimer mimics ... -
Improving Brain Delivery of Biomolecules via BBB Modulation in Mouse and Rat: Detection using MRI, NIRF, and Mass Spectrometry
(Ivyspring International Publisher, 2017-06-08)There is an urgent need to develop new and alternative methods to deliver functional biomolecules to the brain for diagnosis and treatment of brain diseases. The goal of this study was to evaluate the activity of blood-brain ...