Molecular Biosciences Dissertations and Theses: Recent submissions
Now showing items 1-20 of 270
-
Mitotic SUMOylation: Unraveling the role of DNA Topoisomerase IIα SUMOylation and PIASy SUMO E3 ligase in mitosis
(University of Kansas, 2019-12-31)A post-translational modification with SUMO (SUMOylation) can regulate various cellular events such as DNA replication, repair, transcription and cell cycle regulation. Many studies have indicated that SUMOylation is crucial ... -
Polycyclic aromatic hydrocarbons influence naive CD4+ T cell differentiation
(University of Kansas, 2019-12-31)CD4+ T cells are essential for the effective functioning and appropriate regulation of the immune system. Antigen-naïve T cells require two distinct costimulatory signals to activate and differentiate into effector and ... -
THE ROAD LESS TRAVELLED: UTILIZATION OF FORMATE IN TWO BIOCHEMICAL REACTIONS IN GRAM-NEGATIVE BACTERIA
(University of Kansas, 2019-08-31)Formate is an important intermediate in a number of metabolic reactions. Most of the formate pool in cells is generated from the degradation of primary metabolites (glucose, pyruvate, amino acids) and further degraded into ... -
The Biosynthesis of Opine Metallophores
(University of Kansas, 2019-08-31)Metal acquisition is a necessity for all cells as metals are essential for the function of numerous metalloproteins and metalloenzymes. Bacterial pathogens employ several strategies for obtaining necessary metal including ... -
Gene silencing in the nucleus: mechanisms and new phenomena
(University of Kansas, 2019-08-31)Silencing of homologous genes by exogenously introduced dsRNA was first observed in C. elegans. Endogenous small RNAs (siRNAs, piRNAs, miRNAs) mediate regulation of expression of genes post-transcriptionally or at the level ... -
The Bacteriophage
(University of Kansas, 1933-08-31) -
Studies in anaphylaxis
(University of Kansas, 1933-05-31) -
A further study of the antigenic properties of Euglena gracilis, Klebs, with related phenomena
(University of Kansas, 1933-05-31) -
Serological studies of the Reptilia
(University of Kansas, 1938-05-31) -
Designing Small Molecule Inhibitors of RNA-Binding Protein Musashi Using New Biochemical and Computational Approaches
(University of Kansas, 2019-12-31)ABSTRACT RNA-binding proteins (RBPs) are key regulators of post-transcriptional gene expression, and underlie many disease-relevant processes. However, they have historically been challenging to target with drug-like ... -
Activation and Inhibition of Biological Function through Design of Novel Protein-Ligand Interactions
(University of Kansas, 2019-05-31)Virtually every process within a cell involves a protein. They serve as cellular workhorses carrying out functions such as catalysis of essential metabolites, to regulating which genes get turned on or off, to forming the ... -
Predicting the Most Tractable Protein Surfaces in the Human Proteome for Developing New Therapeutics
(University of Kansas, 2019-05-31)A critical step in the target identification phase of drug discovery is evaluating druggability, i.e., whether a protein can be targeted with high affinity using drug-like ligands. The overarching goal of my PhD thesis is ... -
Using Chemical Biology to Modulate Antibody Activity
(University of Kansas, 2019-05-31)Monoclonal antibodies have shown promising results as therapeutic agents, and yet they can also be associated with adverse side effects due to activity outside the disease site. Aiming to reduce these side effects, we have ... -
Cell cycle functions of gamma-tubulin, cyclins, and E3 ubiquitin ligases in Aspergillus nidulans
(University of Kansas, 2018-07-31)In addition to its well-established role in nucleating microtubules at microtubule-organizing centers, γ-tubulin has essential, microtubule-independent functions that are incompletely understood [reviewed in (Oakley et ... -
NEW INSIGHTS INTO THE ROLE OF UNC-6/NETRIN IN GROWTH CONE PROTRUSION, POLARITY AND CYTOSKELETAL ORGANIZATION
(University of Kansas, 2018-08-31)The formation of complex neuronal circuits is crucial for the proper development of the central nervous system. The wiring structure of the nervous system underlies its function in sensation and movement, and higher order ... -
Text Mining for Protein-Protein Docking
(University of Kansas, 2018-08-31)Scientific publications are a rich but underutilized source of structural and functional information on proteins and protein interactions. Although scientific literature is intended for human audience, text mining makes ... -
Current state of tau aggregation inhibitors
(University of Kansas, 2018-05-31)Tau is an intrinsically disordered, heat stable, and highly soluble protein found primarily in the axons of the central nervous system. It belongs to the family of structural microtubule-associated proteins, the major ... -
A Step Closer to Precision Oncology: Computational, Biochemical, and Cell-Based Screening to Find Compounds that Stabilize p53
(University of Kansas, 2018-05-31)Personalized medicine in cancer aims to tailor a treatment plan that takes into account the unique features of a patient's malignancy. One therapeutic target that has a chance to affect a large population of cancer patients ... -
Quorum sensing-controlled genes increase the survival of Chromobacterium violaceum during bacterial interspecies competition
(University of Kansas, 2018-05-31)Many Proteobacteria use a cell-cell communication system called quorum sensing (QS) to coordinate gene expression in a cell density-dependent manner. Cell density is detected through the production and diffusion of ... -
Structure and Function of Podovirus Sf6 Tail Complex
(University of Kansas, 2018-05-31)Sf6 is a double-stranded DNA (dsDNA) bacteriophage with a short, non-contractile tail. The tail is a sophisticated molecular machine made of 39 copies of four gene products, including the dodecameric tail adaptor gp7, the ...