ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated. If you have any questions, please contact Marianne Reed at mreed@ku.edu .

Pharmaceutical Chemistry Scholarly Works: Recent submissions

Now showing items 41-60 of 358

    • Strategies to Screen Anti-AQP4 Antibodies from Yeast Surface Display Libraries 

      Huang, Aric; Jin, Wei; Fahad, Ahmed S.; Mussman, Brooklyn K.; Nicchia, Grazia Paola; Madan, Bharat; de Souza, Matheus Oliveira; Griffin, J. Daniel; Bennett, Jeffrey L.; Frigeri, Antonio; Berkland, Cory J.; DeKosky, Brandon J. (MDPI, 2022-06-05)
      A rapid and effective method to identify disease-specific antibodies from clinical patients is important for understanding autoimmune diseases and for the development of effective disease therapies. In neuromyelitis optica ...

    • Analytical and Preformulation Characterization Studies of Human Papillomavirus Virus-Like Particles to Enable Quadrivalent Multi-Dose Vaccine Formulation Development (Dataset) 

      Jerajani, Kaushal; Wan, Ying; Hickey, John M.; Kumru, Ozan S.; Sharma, Nitya; Pullagurla, Swathi R.; Ogun, Oluwadara; Mapari, Shweta; Whitaker, Neal; Brendle, Sarah; Christensen, Neil D.; Batwal, Saurabh; Mahedvi, Mustafa; Rao, Harish; Dogar, Vikas; Chandrasekharan, Rahul; Shaligram, Umesh; Joshi, Sangeeta B.; Volkin, David B. (Elsevier, 2022)
      Introducing multi-dose formulations of Human Papillomavirus (HPV) vaccines will reduce costs and enable improved global vaccine coverage, especially in low- and middle-income countries. This work describes the development ...

    • Molecular probes of spike ectodomain and its subdomains for SARS-CoV-2 variants, Alpha through Omicron 

      Teng, I-Ting; Nazzari, Alexandra F.; Choe, Misook; Liu, Tracy; de Souza, Matheus Oliveira; Petrova, Yuliya; Tsybovsky, Yaroslav; Wang, Shuishu; Zhang, Baoshan; Artamonov, Mykhaylo; Madan, Bharat; Huang, Aric; Lopez Acevedo, Sheila N.; Pan, Xiaoli; Ruckwardt, Tracy J.; DeKosky, Brandon J.; Mascola, John R.; Misasi, John; Sullivan, Nancy J.; Zhou, Tongqing; Kwong, Peter D. (Public Library of Science, 2022-05-24)
      Since the outbreak of the COVID-19 pandemic, widespread infections have allowed SARS-CoV-2 to evolve in human, leading to the emergence of multiple circulating variants. Some of these variants show increased resistance to ...

    • Antigen-adjuvant interactions, stability, and immunogenicity profiles of a SARS-CoV-2 receptor-binding domain (RBD) antigen formulated with aluminum salt and CpG adjuvants (Datasets) 

      Bajoria, Sakshi; Kaur, Kawaljit; Kumru, Ozan S.; Van Slyke, Greta; Doering, Jennifer; Novak, Hayley; Rodriguez-Aponte, Sergio A.; Dalvie, Neil C.; Naranjo, Christopher A.; Johnston, Ryan S.; Maxwell Silverman, Judith; Kleanthous, Harry; Love, J. Christopher; Mantis, Nicholas J.; Joshi, Sangeeta B.; Volkin, David B. (2022-05-17)
      Low-cost, refrigerator-stable COVID-19 vaccines will facilitate global access and improve vaccine coverage in low-and middle-income countries. To this end, subunit-based approaches targeting the receptor-binding domain ...

    • SARS-CoV-2 receptor binding domain displayed on HBsAg virus–like particles elicits protective immunity in macaques 

      Dalvie, Neil C.; Tostanoski, Lisa H.; Rodriguez-Aponte, Sergio A.; Kaur, Kawaljit; Bajoria, Sakshi; Kumru, Ozan S.; Martinot, Amanda J.; Chandrashekar, Abishek; McMahan, Katherine; Mercado, Noe B.; Yu, Jingyou; Chang, Aiquan; Giffin, Victoria M.; Nampanya, Felix; Patel, Shivani; Bowman, Lesley; Naranjo, Christopher A.; Yun, Dongsoo; Flinchbaugh, Zach; Pessaint, Laurent; Brown, Renita; Velasco, Jason; Teow, Elyse; Cook, Anthony; Andersen, Hanne; Lewis, Mark G.; Camp, Danielle L.; Silverman, Judith Maxwell; Nagar, Gaurav S.; Rao, Harish D.; Lothe, Rakesh R.; Chandrasekharan, Rahul; Rajurkar, Meghraj P.; Shaligram, Umesh S.; Kleanthous, Harry; Joshi, Sangeeta B.; Volkin, David B.; Biswas, Sumi; Love, J. Christopher; Barouch, Dan H. (American Association for the Advancement of Science, 2022-03-16)
      Authorized vaccines against SARS-CoV-2 remain less available in low- and middle-income countries due to insufficient supply, high costs, and storage requirements. Global immunity could still benefit from new vaccines using ...

    • Formulation development of a live attenuated human rotavirus (RV3-BB) vaccine candidate for use in low- and middle-income countries 

      Kumar, Prashant; Shukla, Ravi S.; Patel, Ashaben; Pullagurla, Swathi R.; Bird, Christopher; Ogun, Oluwadara; Kumru, Ozan S.; Hamidi, Ahd; Hoeksema, Femke; Yallop, Christopher; Bines, Julie E.; Joshi, Sangeeta B.; Volkin, David B. (Taylor and Francis, 2021-04-16)
      Formulation development was performed with the live, attenuated, human neonatal rotavirus vaccine candidate (RV3-BB) with three main objectives to facilitate use in low- and middle- income countries including (1) a liquid, ...

    • Intratumoral Cancer Chemotherapy with a Carrier-Based Immunogenic Cell-Death Eliciting Platinum (IV) Agent 

      Groer, Chad; Zhang, Ti; Lu, Ruolin; Cai, Shuang; Mull, Derek; Huang, Aric; Forrest, Melanie; Berkland, Cory; Aires, Daniel; Forrest, Marcus Laird (American Chemical Society, 2020-09-25)
      A carrier-based, immunogenic cell death (ICD)-eliciting platinum(IV) chemotherapeutic agent was synthesized via complexation between an axially derivatized Pt(IV)-tocopherol and hyaluronan (HA)–tocopherol nanocarrier. The ...

    • Development of a Broadly Protective, Self-Adjuvanting Subunit Vaccine to Prevent Infections by Pseudomonas aeruginosa 

      Das, Sayan; Howlader, Debaki R.; Zheng, Qi; Ratnakaram, Siva Sai Kumar; Whittier, Sean K.; Lu, Ti; Keith, Johnathan D.; Picking, William D.; Birket, Susan E.; Picking, Wendy L. (Frontiers Media, 2020-11-17)
      Infections caused by the opportunistic pathogen Pseudomonas aeruginosa can be difficult to treat due to innate and acquired antibiotic resistance and this is exacerbated by the emergence of multi-drug resistant strains. ...

    • Preformulation Characterization and the Effect of Ionic Excipients on the Stability of a Novel DB Fusion Protein 

      Jain, Akshay; Hu, Gang; Ratnakaram, Siva Sai Kumar; Johnson, David K.; Picking, William D.; Picking, Wendy L.; Middaugh, Charles Russell (Frontiers Media, 2021-01-01)
      Shigella ssp cause bacillary dysentery (shigellosis) which has high global morbidity in young children and the elderly. The virulence of Shigella relies upon a type III secretion system (T3SS) which injects host altering ...

    • Effect of Formulation Variables on the Stability of a Live, Rotavirus (RV3-BB) Vaccine Candidate using in vitro Gastric Digestion Models to Mimic Oral Delivery 

      Kumar, Prashant; Pullagurla, Swathi R.; Patel, Ashaben; Shukla, Ravi S.; Bird, Christopher; Kumru, Ozan S.; Hamidi, Ahd; Hoeksema, Femke; Yallop, Christopher; Bines, Julie E.; Joshi, Sangeeta B.; Volkin, David B. (Wiley, 2020-10-06)
      In this work, two different in vitro gastric digestion models were used to evaluate the stability of a live attenuated rotavirus vaccine candidate (RV3-BB) under conditions designed to mimic oral delivery in infants. First, ...

    • Synthetic Cationic Autoantigen Mimics Glatiramer Acetate Persistence at the Site of Injection and Is Efficacious Against Experimental Autoimmune Encephalomyelitis 

      Song, Jimmy Y.; Griffin, J. Daniel; Larson, Nicholas R.; Christopher, Matthew A.; Middaugh, C. Russell; Berkland, Cory J. (Frontiers Media, 2021-01-18)
      A synthetic peptide, K-PLP, consisting of 11-unit poly-lysine (K11) linked via polyethylene glycol (PEG) to proteolipid protein epitope (PLP) was synthesized, characterized, and evaluated for efficacy in ameliorating ...

    • Investigation of a monoclonal antibody against enterotoxigenic Escherichia coli, expressed as secretory IgA1 and IgA2 in plants 

      Teh, Audrey Y-H; Cavacini, Lisa; Hu, Yue; Kumru, Ozan S.; Xiong, Jian; Bolick, David T.; Joshi, Sangeeta B.; Grünwald-Gruber, Clemens; Altmann, Friedrich; Klempner, Mark; Guerrant, Richard L.; Volkin, David B.; Wang, Yang; Ma, Julian K-C. (Taylor & Francis Open Access, 2021-01-13)
      Passive immunization with antibodies is a promising approach against enterotoxigenic Escherichia coli diarrhea, a prevalent disease in LMICs. The objective of this study was to investigate expression of a monoclonal anti-ETEC ...

    • The Shigella Type III Secretion System: An Overview from Top to Bottom 

      Muthuramalingam, Meenakumari; Whittier, Sean K.; Picking, Wendy L.; Picking, William D. (MDPI, 2021-02-22)
      Shigella comprises four species of human-restricted pathogens causing bacillary dysentery. While Shigella possesses multiple genetic loci contributing to virulence, a type III secretion system (T3SS) is its primary virulence ...

    • Functional Profiling of Antibody Immune Repertoires in Convalescent Zika Virus Disease Patients 

      Fahad, Ahmed S.; Timm, Morgan R.; Madan, Bharat; Burgomaster, Katherine E.; Dowd, Kimberly A.; Normandin, Erica; Gutiérrez-González, Matías F.; Pennington, Joseph M.; De Souza, Matheus Oliveira; Henry, Amy R.; Laboune, Farida; Wang, Lingshu; Ambrozak, David R.; Gordon, Ingelise J.; Douek, Daniel C.; Ledgerwood, Julie E.; Graham, Barney S.; Castilho, Leda R.; Pierson, Theodore C.; Mascola, John R.; DeKosky, Brandon J. (Frontiers Media, 2021-02-24)
      The re-emergence of Zika virus (ZIKV) caused widespread infections that were linked to Guillain-Barré syndrome in adults and congenital malformation in fetuses, and epidemiological data suggest that ZIKV infection can ...

    • Lung Surfactant Decreases Biochemical Alterations and Oxidative Stress Induced by a Sub-Toxic Concentration of Carbon Nanoparticles in Alveolar Epithelial and Microglial Cells 

      Caruso, Giuseppe; Fresta, Claudia G.; Costantino, Angelita; Lazzarino, Giacomo; Amorini, Angela M.; Lazzarino, Giuseppe; Tavazzi, Barbara; Lunte, Susan M.; Dhar, Prajnaparamita; Gulisano, Massimo; Caraci, Filippo (MDPI, 2021-03-07)
      Carbon-based nanomaterials are nowadays attracting lots of attention, in particular in the biomedical field, where they find a wide spectrum of applications, including, just to name a few, the drug delivery to specific ...

    • Molecular engineering improves antigen quality and enables integrated manufacturing of a trivalent subunit vaccine candidate for rotavirus 

      Dalvie, Neil C.; Brady, Joseph R.; Crowell, Laura E.; Tracey, Mary Kate; Biedermann, Andrew M.; Kaur, Kawaljit; Hickey, John M.; Kristensen, D. Lee, II; Bonnyman, Alexandra D.; Rodriguez-Aponte, Sergio A.; Whittaker, Charles A.; Bok, Marina; Vega, Celina; Mukhopadhyay, Tarit K.; Joshi, Sangeeta B.; Volkin, David B.; Parreño, Viviana; Love, Kerry R.; Love, J. Christopher (BMC, 2021-05-01)
      Background Vaccines comprising recombinant subunit proteins are well-suited to low-cost and high-volume production for global use. The design of manufacturing processes to produce subunit vaccines depends, however, on the ...

    • Carnosine Protects Macrophages against the Toxicity of Aβ1-42 Oligomers by Decreasing Oxidative Stress 

      Caruso, Giuseppe; Benatti, Cristina; Musso, Nicolò; Fresta, Claudia G.; Fidilio, Annamaria; Spampinato, Giorgia; Brunello, Nicoletta; Bucolo, Claudio; Drago, Filippo; Lunte, Susan M.; Peterson, Blake R.; Tascedda, Fabio; Caraci, Filippo (MDPI, 2021-04-26)
      Carnosine (β-alanyl-L-histidine) is a naturally occurring endogenous peptide widely distributed in excitable tissues such as the brain. This dipeptide has well-known antioxidant, anti-inflammatory, and anti-aggregation ...

    • Developing a manufacturing process to deliver a cost effective and stable liquid human rotavirus vaccine 

      Hamidi, Ahd; Hoeksema, Femke; Velthof, Pim; Lemckert, Angelique; Gillissen, Gert; Luitjens, Alfred; Bines, Julie E.; Pullagurla, Swathi R.; Kumar, Prashant; Volkin, David B.; Joshi, Sangeeta B.; Havenga, Menzo; Bakker, Wilfried A.M.; Yallop, Christopher (Elsevier, 2021-04-08)
      Despite solid evidence of the success of rotavirus vaccines in saving children from fatal gastroenteritis, more than 82 million infants worldwide still lack access to a rotavirus vaccine. The main barriers to global rotavirus ...

    • Sequence-Signature Optimization Enables Improved Identification of Human HV6-1-Derived Class Antibodies That Neutralize Diverse Influenza A Viruses 

      Chuang, Gwo-Yu; Shen, Chen-Hsiang; Cheung, Crystal Sao-Fong; Gorman, Jason; Creanga, Adrian; Joyce, M. Gordon; Leung, Kwanyee; Rawi, Reda; Wang, Lingshu; Yang, Eun Sung; Yang, Yongping; Zhang, Baoshan; Zhang, Yi; Kanekiyo, Masaru; Zhou, Tongqing; DeKosky, Brandon J.; Graham, Barney S.; Mascola, John R.; Kwong, Peter D. (Frontiers Media, 2021-05-31)
      Sequence signatures of multidonor broadly neutralizing influenza antibodies can be used to quantify the prevalence of B cells with virus-neutralizing potential to accelerate development of broadly protective vaccine ...

    • Composition and Biophysical Properties of the Sorting Platform Pods in the Shigella Type III Secretion System 

      Tachiyama, Shoichi; Skaar, Ryan; Chang, Yunjie; Carroll, Brittany L.; Muthuramalingam, Meenakumari; Whittier, Sean K.; Barta, Michael L.; Picking, Wendy L.; Liu, Jun; Picking, William D. (Frontiers Media, 2021-06-03)
      Shigella flexneri, causative agent of bacillary dysentery (shigellosis), uses a type III secretion system (T3SS) as its primary virulence factor. The T3SS injectisome delivers effector proteins into host cells to promote ...